It makes complete sense to exclude people with severe allergies from the trials if you believe severe allergies are likely to affect the health and safety of th

It makes complete sense to exclude people with severe allergies from the trials if you believe severe allergies are likely to affect the health and safety of the vaccine. This is fairly common for vaccines. It's not cutting corners either. If you expect severe allergies to adversely affect outcomes, you don't gain anything from having them in your general trial population, because unless you make sure your data gather and trial protocols are designed to test for the difference, you're unlikely to be able to form a robust opinion on the safety of the drug for allergy sensitive people, but are highly likely to taint your understanding of how it affects "normal" people. (that is, you could probably observe risk fairly easily, but you wouldn't be sure to confirm its safe for them if nothing showed up) There might be something about being conservative to avoid what happened to these people without notice, but in the scheme of things its a pretty small pain point.