Relevant to note though that with the Game Boy, at least originally anyway, developers knew exactly what screen was being played on, and occasionally used that

Relevant to note though that with the Game Boy, at least originally anyway, developers knew exactly what screen was being played on, and occasionally used that knowledge to fake effects that wouldn't been possible on a CRT. See for example the space shooter ZAS which flickers between multiple layers to simulate blending and parallax scrolling, effects which weren't otherwise possible on such a limited system (and using a mechanism which wouldn't have yielded acceptable results on a CRT): https://www.youtube.com/watch?v=Ty-qFeYK2l8&t=366s https://www.youtube.com/watch?v=Ty-qFeYK2l8&t=366s