If by compete, you mean "beat" Amazon, that isn't going to happen. If you mean "compete" as in "make a living selling stuff online", you can compete very well

If by compete, you mean "beat" Amazon, that isn't going to happen. If you mean "compete" as in "make a living selling stuff online", you can compete very well against Amazon, as well as any other online retailer. You need a solid product that people want to buy, and carve your niche.