3 ms·

I personally know multiple people that became intolerant to beef after a tick bite, rather than all mammalian meat. The symptoms manifested as digestive stress

I personally know multiple people that became intolerant to beef after a tick bite, rather than all mammalian meat. The symptoms manifested as digestive stress: abdominal cramping, nausea, and diarrhea. The onset of symptoms might be delayed for minutes or hours. In one case, the person started to lose ability to tolerate a wide variety of foods. Further investigation revealed some symptoms that seemed to be related to MTHFR mutations. Genetic analysis confirmed this. Prior to analysis, began supplementing with 5-methyltetrahydrofolate. This began to immediately improve symptoms and foods were able to be added back to the diet. This continue for some time and hit a wall. Eventually traditional Chinese medicine doctor prescribed some herbal supplements. The person in question still avoids beef, but is otherwise back to their pre-tickbite diet and living a normal life after years of struggling.

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Bjartr 6y ago
So was it beef sensitivity or just a folate deficiency?
- linuxftw 6y ago
  Something about the beef sensitivity (possibly caused by a confirmed tick bite) seemed to cause the situation to spiral into more food intolerances. Symptoms started to mimic others with an MTHFR mutation. That mutation results in less production of some enzyme that metabolizes folate into another form (eventually leading to the form I posted 5-something-or-other). Taking that supplement allows you to bypass the folate conversion metabolic pathway. How does this all fit together? I'm not entirely sure, this is an emerging area of research, I can only share what worked for the person I know. This MTHFR business seems to be related to histamine levels as well, that methlylated folate seems to be used by the liver to metabolize histamine. This seems to be directly related to allergic immune responses. Hypothesis: Most people can tolerate the small amount of immune response triggered by the a-gal protein. People with MTHFR mutations cannot. The exact causative pathway, TBD.

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Bjartr 6y ago

So was it beef sensitivity or just a folate deficiency?

linuxftw 6y ago
Something about the beef sensitivity (possibly caused by a confirmed tick bite) seemed to cause the situation to spiral into more food intolerances. Symptoms started to mimic others with an MTHFR mutation. That mutation results in less production of some enzyme that metabolizes folate into another form (eventually leading to the form I posted 5-something-or-other). Taking that supplement allows you to bypass the folate conversion metabolic pathway. How does this all fit together? I'm not entirely sure, this is an emerging area of research, I can only share what worked for the person I know. This MTHFR business seems to be related to histamine levels as well, that methlylated folate seems to be used by the liver to metabolize histamine. This seems to be directly related to allergic immune responses. Hypothesis: Most people can tolerate the small amount of immune response triggered by the a-gal protein. People with MTHFR mutations cannot. The exact causative pathway, TBD.