4 ms·

Maybe some dont like to hear this, but publishing in PNAS is usually when your publication is rejected from other more respected peer-reviewed journals. I wont

Maybe some dont like to hear this, but publishing in PNAS is usually when your publication is rejected from other more respected peer-reviewed journals. I wont trust this publication much.

hombre_fatal 6y ago
Either way, the only actionable morsel I think anyone could take from this if such a person existed is that they probably don’t need to buy Cytosport’s expensive Muscle Serum(tm) and rip it mid-workout, something that probably does the average person no good anyways beyond turning their piss neon green. Not that anyone changes their life over a scientific paper. The other year I read part of a frightening paper on heart disease that had me google “how to prevent atherosclerosis”, and later that day I stopped through the McD drive-thru just for three large fries. Gonna have to come at something a little harder hitting than science to inconvenience me, baby!
gryson 6y ago
Bizarre comment - are you taking the old PNAS = "Passed over by Nature And Science" joke a bit too literally? PNAS is one of the top general-science journals. Yes, there are better field-specific journals, but PNAS is pretty damn respectable and not that easy to get published in. Regardless, a publication should be judged on the strength of its research, not on which top-tier journal it is in.
- SubiculumCode 6y ago
  Nature and Science. Ha. If "good" journals stopped with Science and Nature, I wouldn't have published anything yet. Lots of solid science won't even get considered at those journals.
andor 6y ago
I have heard better arguments in scientific discourse ;-) Given that vitamin C supplementation is generally understood to inhibit some training adaptations (e.g. reduced skeletal muscle growth), it sounds reasonable to me that it might also prevent insulin sensitivity improvements. Insulin triggers glycogen synthesis and muscles are one of the places where this happens. Reduced muscle growth -> reduced change in glycogenesis capacity.
- mrfusion 6y ago
  What’s the deal about vitamin c and muscle growth? Can you suggest further reading? What’s the best way to take vitamin c then? Load up on off days, skip on training days? I like taking 1000mg/day for the gum health benefits and cold prevention.
  - andor 6y ago
    I recommend searching for "vitamin c training adaptation" on Google Scholar. You'll get a few results plus a list of citations for each result (click "cited by"). The citations help to put each paper into context. The general idea is that high doses of antioxidants influence cellular pathways that are usually triggered by the presence of reactive oxygen species. The vitamin C reacts with the ROS before the body can build up a response. I'm not a coach or nutritionist, I can't give a good recommendation. I think the trend goes towards supplementing as little as possible and instead eating enough fruit and whole foods. The body is extremely complex (check out http://biochemical-pathways.com/ http://biochemical-pathways.com/), supplementing with high dosage might have consequences we don't understand yet. Personally I stopped taking vitamin C a while ago and have not noticed a difference. "Dylan Johnson" is a coach who gives science-based recommendations, he has a video on Youtube about vitamin C.
SubiculumCode 6y ago
PNAS is a well respected, high impact journal. Impact factors aren't everything, but: 2019 Impact Factor: 9.41 There is no nice way to say this, but your comment is ignorant. I can’t imagine anyone who has published anywhere making this comment
- faeyanpiraat 6y ago
  Could you please help me out with a method for how can I determine a paper's legitimacy in a field I'm not familiar with? What is a good impact factor for the publiching journal? What is a good # of citations? What other factors should I check?
  - SubiculumCode 6y ago
    Its a little complicated when it comes to impact factors and sub-discipline journals. In my field, specialized journals on developmental psychology, highly respected journals have an impact factor around 4 or 5, like "Child Development" Psychology journals with impact factors around 2 to 3 are kind of the journals you publish in after trying others first, or if you just have a little study that needs publishing, but the results were not that interesting, or if there are some more serious issues in the design, but still worth publishing, etc. In the past I automatically suspected any journal with an impact factor less than 1 or 2 as being trash, but, it has recently come to my attention that there are highly respected journals with really low impact factors, just because it publishes on a highly specialized subfield, and thus don't get cited as frequently. So all in all, as an outsider, it can be a bit difficult. One possible way is to refer to SJR rankings by discipline: https://www.scimagojr.com/journalrank.php?category=2801 https://www.scimagojr.com/journalrank.php?category=2801 but this still fails for the extra specialized journals. Another possibility is to look at what authors are publishing in the journal. Are they from major research Universities? etc. But for a general rule of thumb: any journal with an impact over 2 is a legitimate journal, and any journal with an impact of 6 or more is a very solid journal, 9 up are considered top tier, 14 up are elite tiered.
mikesabbagh 6y ago
Just look at that bizarre title: "Antioxidants prevent health-promoting effects of physical exercise" I mean come on!! How can such a generalization be allowed. I was lucky to study in a great lab, my name is on several papers Nature, Science, Nature Medicine and others. PNAS was always our last resort

Maybe some dont like to hear this, but publishing in PNAS is usually when your publication is rejected from other more respected peer-reviewed journals. I wont trust this publication much.

hombre_fatal 6y ago

Either way, the only actionable morsel I think anyone could take from this if such a person existed is that they probably don’t need to buy Cytosport’s expensive Muscle Serum(tm) and rip it mid-workout, something that probably does the average person no good anyways beyond turning their piss neon green. Not that anyone changes their life over a scientific paper. The other year I read part of a frightening paper on heart disease that had me google “how to prevent atherosclerosis”, and later that day I stopped through the McD drive-thru just for three large fries. Gonna have to come at something a little harder hitting than science to inconvenience me, baby!

gryson 6y ago

Bizarre comment - are you taking the old PNAS = "Passed over by Nature And Science" joke a bit too literally? PNAS is one of the top general-science journals. Yes, there are better field-specific journals, but PNAS is pretty damn respectable and not that easy to get published in. Regardless, a publication should be judged on the strength of its research, not on which top-tier journal it is in.

SubiculumCode 6y ago
Nature and Science. Ha. If "good" journals stopped with Science and Nature, I wouldn't have published anything yet. Lots of solid science won't even get considered at those journals.

andor 6y ago

I have heard better arguments in scientific discourse ;-) Given that vitamin C supplementation is generally understood to inhibit some training adaptations (e.g. reduced skeletal muscle growth), it sounds reasonable to me that it might also prevent insulin sensitivity improvements. Insulin triggers glycogen synthesis and muscles are one of the places where this happens. Reduced muscle growth -> reduced change in glycogenesis capacity.

mrfusion 6y ago
What’s the deal about vitamin c and muscle growth? Can you suggest further reading? What’s the best way to take vitamin c then? Load up on off days, skip on training days? I like taking 1000mg/day for the gum health benefits and cold prevention.
- andor 6y ago
  I recommend searching for "vitamin c training adaptation" on Google Scholar. You'll get a few results plus a list of citations for each result (click "cited by"). The citations help to put each paper into context. The general idea is that high doses of antioxidants influence cellular pathways that are usually triggered by the presence of reactive oxygen species. The vitamin C reacts with the ROS before the body can build up a response. I'm not a coach or nutritionist, I can't give a good recommendation. I think the trend goes towards supplementing as little as possible and instead eating enough fruit and whole foods. The body is extremely complex (check out http://biochemical-pathways.com/ http://biochemical-pathways.com/), supplementing with high dosage might have consequences we don't understand yet. Personally I stopped taking vitamin C a while ago and have not noticed a difference. "Dylan Johnson" is a coach who gives science-based recommendations, he has a video on Youtube about vitamin C.

SubiculumCode 6y ago

PNAS is a well respected, high impact journal. Impact factors aren't everything, but: 2019 Impact Factor: 9.41 There is no nice way to say this, but your comment is ignorant. I can’t imagine anyone who has published anywhere making this comment

faeyanpiraat 6y ago
Could you please help me out with a method for how can I determine a paper's legitimacy in a field I'm not familiar with? What is a good impact factor for the publiching journal? What is a good # of citations? What other factors should I check?
- SubiculumCode 6y ago
  Its a little complicated when it comes to impact factors and sub-discipline journals. In my field, specialized journals on developmental psychology, highly respected journals have an impact factor around 4 or 5, like "Child Development" Psychology journals with impact factors around 2 to 3 are kind of the journals you publish in after trying others first, or if you just have a little study that needs publishing, but the results were not that interesting, or if there are some more serious issues in the design, but still worth publishing, etc. In the past I automatically suspected any journal with an impact factor less than 1 or 2 as being trash, but, it has recently come to my attention that there are highly respected journals with really low impact factors, just because it publishes on a highly specialized subfield, and thus don't get cited as frequently. So all in all, as an outsider, it can be a bit difficult. One possible way is to refer to SJR rankings by discipline: https://www.scimagojr.com/journalrank.php?category=2801 https://www.scimagojr.com/journalrank.php?category=2801 but this still fails for the extra specialized journals. Another possibility is to look at what authors are publishing in the journal. Are they from major research Universities? etc. But for a general rule of thumb: any journal with an impact over 2 is a legitimate journal, and any journal with an impact of 6 or more is a very solid journal, 9 up are considered top tier, 14 up are elite tiered.

mikesabbagh 6y ago

Just look at that bizarre title: "Antioxidants prevent health-promoting effects of physical exercise" I mean come on!! How can such a generalization be allowed. I was lucky to study in a great lab, my name is on several papers Nature, Science, Nature Medicine and others. PNAS was always our last resort