4 ms·
A controversial topic .. there is an effect called mito-hormesis .. when you do excercise there are small amount of free radicals leaked that activates kinases
by seesawtron 6y ago
A controversial topic .. there is an effect called mito-hormesis .. when you do excercise there are small amount of free radicals leaked that activates kinases and inhibits phosphatades and overall increase phosphorylation in the cell. Through this and other pathways, some genes are expressed which are supposed to increase survival, so overall there is a window of free raficals concentration. If you get below it (total blockade) you will prevent the hormesis (beneficial) effect, but if you get above it, you can get all the free radical related diseases e.g neurodegenerative diseases.
[0] https://doi.org/10.1038/nm.3624 https://doi.org/10.1038/nm.3624
- agumonkey 6y agowhat's the status quo on hormesis acceptance ? I've read countless time that the originator is controversial and over-fit his theory .. but at the same time positive/antifragile feedback mechanisms seem so obvious.
- refurb 6y agoAre you thinking radiation hormesis? That is still controversial and current radiation safety standards adhere to "no safe dose of radiation". But hormesis as a general theory (i.e. "small doses are beneficial, large doses harmful") isn't really that controversial.
- agumonkey 6y agoI remember a lot of time reading people saying the general theory is fluff because too general.
- seesawtron 6y agoI am not an expert on the ageing-related hormesis topic and have not kept up with status quo but this was the most recent and interesting interactive lecture I enjoyed this year on the topic: https://youtu.be/zjQ5Z7v6csk https://youtu.be/zjQ5Z7v6csk