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The mechanism for how these vaccines work is pretty straightforward, well understood, and quick acting. They trigger your immune system to be aware of a threat
by Exmoor 6y ago
The mechanism for how these vaccines work is pretty straightforward, well understood, and quick acting. They trigger your immune system to be aware of a threat and train it to defeat that threat. This is something your body does fairly constantly with natural pathogens without any known delayed long-term effects.
This idea that there is some sort of known risk of a significant issue popping up out of nowhere months or years down the road has no historical precedent. The two modern (last 50 years) incidences where a vaccine may have caused a serious side effect in a statistically significant way [0][1] may have taken a little bit of time to be noticed, but it was because they were so statistically rare, not because the actual problem was delayed in occurring. Interestingly, both those incidents involved auto-immune illnesses which would have likely been much more likely to occur if the vaccinated folks caught the virus itself.
[0] https://en.wikipedia.org/wiki/Pandemrix https://en.wikipedia.org/wiki/Pandemrix
[1] https://en.wikipedia.org/wiki/1976_swine_flu_outbreak https://en.wikipedia.org/wiki/1976_swine_flu_outbreak
- generalizations 6y ago> The mechanism for how these vaccines work is pretty straightforward, well understood, and quick acting. Before 2020, mRNA was only considered a theoretical or experimental candidate for use in humans. Sure, we have a theory behind the mechanism, but that's it. Your implication that we know all about what these novel, unfamiliar mRNA vaccines will do is flat out wrong. > This idea that there is some sort of known risk of a significant issue popping up out of nowhere months or years down the road has no historical precedent. That's because there's almost no precedent at all. https://link.springer.com/protocol/10.1007%2F978-1-4939-6481-9_1 https://link.springer.com/protocol/10.1007%2F978-1-4939-6481... https://en.wikipedia.org/wiki/RNA_vaccines https://en.wikipedia.org/wiki/RNA_vaccines
- oicu812 6y ago> This idea that there is some sort of known risk of a significant issue popping up out of nowhere months or years down the road has no historical precedent. RotaShield [0] was a vaccine for the rotavirus that was released in 1998 and taken off the market in 1999 because of intussusception (bowel folding on itself). 5 cases of this issue occurred during during trials of 10,054 participants, which was deemed "not statistically significant". After the vaccine was licensed and widely distributed, the CDC determined the risk of this complication from the vaccine was 20 to 30 times over the expected risk and the vaccine was pulled off the market. [0] https://www.cdc.gov/vaccines/vpd-vac/rotavirus/vac-rotashield-historical.htm https://www.cdc.gov/vaccines/vpd-vac/rotavirus/vac-rotashiel...