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There are still 486-class single board computers (SBC) available w/ PC/104 interfaces (which is electrically the ISA bus but on a pin header). I believe there a

There are still 486-class single board computers (SBC) available w/ PC/104 interfaces (which is electrically the ISA bus but on a pin header). I believe there are boards that let you interface card-edge connector slots to a PC/104 SBC.

rzzzt 6y ago
LGR has made a video recently, installing one (it had an ISA edge connector, not PC/104) with a backplane in a desktop case: https://youtu.be/Q4qJf50YSVk https://youtu.be/Q4qJf50YSVk