4 ms·
Arm A – CAB LA (as an intramuscular injection every 8 weeks) and daily oral TDF/FTC placebo. Arm B – Daily oral TDF/FTC and intramuscular CAB LA placebo every 8
by xiphias2 6y ago
Arm A – CAB LA (as an intramuscular injection every 8 weeks) and daily oral TDF/FTC placebo.
Arm B – Daily oral TDF/FTC and intramuscular CAB LA placebo every 8 weeks.
Taking an oral medication + injection every 8 weeks looks a little bit too hard to follow to me for preventing HIV acquisition. I'm more optimistic for HIV vaccines on the long term, though right now it's not the highest priority for the 2 mRNA vaccine winners. BioNTech has HIV vaccine in preclicical stage though: https://biontech.de/science/pipeline https://biontech.de/science/pipeline
- gizmo686 6y agoYou don't need both. The new treatment is only a bi-monthly injection. Study participants only needs both the injection and daily oral medication due to the study design. Since they were comparing the new (injection) treatment with an old (oral) treatment, participants needed to go through the motions of both so that they could be properly blinded.
- xiphias2 6y agoAh sorry, I didn’t read it carefully enough, thanks for the explanation!
- abeppu 6y ago> Taking an oral medication + injection every 8 weeks looks a little bit too hard to follow to me for preventing HIV acquisition. In the US, PrEP is normally a daily pill, plus testing (typically an in-office blood draw) for both HIV but also kidney function every 90 days. 8 weeks vs 90 days isn't _that_ different, and visiting a health care provider to get an injection vs a blood draw seems quite similar. So in terms of patient experience, this treatment + placebo combination during their trial doesn't seem that far off from what a lot of people are already doing. The prospect of moving to _only_ the long-term injection (and perhaps supporting tests done at the same time?) would be appealing for many.