Great comment. It appears to be a huge problem in synthetic biology too. For instance you can often, using genetic programming, find a gene that is far more fit

Great comment. It appears to be a huge problem in synthetic biology too. For instance you can often, using genetic programming, find a gene that is far more fit than anything synthetic bioengineering would produce. The problem is genetic programming is undocumented, so you don't know how/why the gene is fit.