6 ms·

Well, fwiw, the inventor of the mRNA vaccine idea, Ingmar Hoerr, thinks side effects are very unlikely, since the mRNA molecules dissolve after a few days. He

Well, fwiw, the inventor of the mRNA vaccine idea, Ingmar Hoerr, thinks side effects are very unlikely, since the mRNA molecules dissolve after a few days. He has been working on this for 20 years, with no serious side effects ever observed. https://en.wikipedia.org/wiki/Ingmar_Hoerr https://en.wikipedia.org/wiki/Ingmar_Hoerr

john_alan 6y ago
Was the SARS vaccine virus not mRNA?
- apexalpha 6y ago
  Yes, this is why these mRNA vaccines are here so fast; a lot of prework was done for SARS vaccine, which is also a Corona disease. But I think SARS died out before the vaccine was ready/needed.
  - patall 6y ago
    the parent is concerned regarding the appearance of ADE (Antibody-dependent enhancement) during the creation of the SARS vaccine. While we cannot totally disregard ADE, I assume we should have seen it by now (and the Oxford trial was stopped exactly because they thought they might have observed something like it). Whether it appears again on a population scale level, nobody knows.
    - SomeoneFromCA 6y ago
      Yeah, I've thought about it too, but both mild reinfections and vaccine trials show that SARS-2 does not exhibit ADE.
    - jonstaab 6y ago
      I don't know anything, but I've read that ADE can take 1-3 years to surface.
Scaevolus 6y ago
There _are_ acute side effects, basically equivalent to a strong viral effection. I agree that long term side effects are unlikely. https://www.nejm.org/doi/full/10.1056/NEJMoa2022483 https://www.nejm.org/doi/full/10.1056/NEJMoa2022483
- stjohnswarts 6y ago
  *possible, and in low % of people, and none have been shown to be more than a few days.
  - Scaevolus 6y ago
    A lot of these side-effects affect >50% of people (phase 3 dosage is 100ug), including fatigue, chills, headache, muscle pain, nausea, and pain. 100% of the 100ug treatment group had at least one symptom, 80% of those classified as moderate. The vaccine is going to make you feel sick for a little while.
deleted 6y ago
[deleted]

john_alan 6y ago

Was the SARS vaccine virus not mRNA?

apexalpha 6y ago
Yes, this is why these mRNA vaccines are here so fast; a lot of prework was done for SARS vaccine, which is also a Corona disease. But I think SARS died out before the vaccine was ready/needed.
- patall 6y ago
  the parent is concerned regarding the appearance of ADE (Antibody-dependent enhancement) during the creation of the SARS vaccine. While we cannot totally disregard ADE, I assume we should have seen it by now (and the Oxford trial was stopped exactly because they thought they might have observed something like it). Whether it appears again on a population scale level, nobody knows.
  - SomeoneFromCA 6y ago
    Yeah, I've thought about it too, but both mild reinfections and vaccine trials show that SARS-2 does not exhibit ADE.
  - jonstaab 6y ago
    I don't know anything, but I've read that ADE can take 1-3 years to surface.

Scaevolus 6y ago

There _are_ acute side effects, basically equivalent to a strong viral effection. I agree that long term side effects are unlikely. https://www.nejm.org/doi/full/10.1056/NEJMoa2022483 https://www.nejm.org/doi/full/10.1056/NEJMoa2022483

stjohnswarts 6y ago
*possible, and in low % of people, and none have been shown to be more than a few days.
- Scaevolus 6y ago
  A lot of these side-effects affect >50% of people (phase 3 dosage is 100ug), including fatigue, chills, headache, muscle pain, nausea, and pain. 100% of the 100ug treatment group had at least one symptom, 80% of those classified as moderate. The vaccine is going to make you feel sick for a little while.

deleted 6y ago

[deleted]