5 ms·
> Yes, it's entirely possible to converge on a wrong structure I guess my question is, how do you know if you’ve converged on the right structure or not? Is th
by selestify 6y ago
> Yes, it's entirely possible to converge on a wrong structure
I guess my question is, how do you know if you’ve converged on the right structure or not? Is there a different experiment you could do?
- dnautics 6y agoBest is an orthogonal process (like NMR). Cryo-EM is getting better too so maybe that will start to be viable. Sometimes that's not possible, but you can use secondary evidence: "we know these three amino acids are important band hey look they touch in our model".