I've long been an AI/ML positivist in the field of protein structure prediction (but not in drug discovery in general), admittedly a bit surprised it was now an

I've long been an AI/ML positivist in the field of protein structure prediction (but not in drug discovery in general), admittedly a bit surprised it was now and not 3-4 years from now... And for a long time I have been saying that a "heuristic" model for folding is going to win (and it looks like it has). However, I would also caution that, there are going to be protein structures that are not in the opus of known structures (being able to solve the structure at all is itself a biasing factor) and AlphaFold's capability to figure those out will be interesting. I would not necessarily be confident it could. (think of issues, like face detection algorithms not being able to correctly identify minorities, e.g.)