3 ms·

Well, you'd be surprised how much great research doesn't make it into Nature, et al. I wouldn't discount the paper purely because of that.

UShouldBWorking 6y ago
Also, an actual peer reviewed paper came out recently that showed giving vitamin d to covid patients upon admitting them did not decrease death rates. I'll look for the link but it was front page here like two weeks ago.
- coding123 6y ago
  Please find the link because about 2 / 3 months ago there was a story that was exactly the opposite finding. https://news.ycombinator.com/item?id=24366006 https://news.ycombinator.com/item?id=24366006 I've been monitoring HN for Vitamin D info very closely.
  - zamfi 6y ago
    I think the parent poster is referring to https://www.medrxiv.org/content/10.1101/2020.11.16.20232397v1 https://www.medrxiv.org/content/10.1101/2020.11.16.20232397v... (Can't find the HN discussion link at the moment, unfortunately -- it didn't point to that particular link!) Worth noting that this RCT was for bolus supplementation of Vitamin D3 at some point in their hospital stay, and excluded patients already supplementing with D3. This study stands in stark contrast to the earlier pilot out of Spain: https://www.sciencedirect.com/science/article/pii/S0960076020302764?via%3Dihub#bib0100 https://www.sciencedirect.com/science/article/pii/S096007602... -- though as noted, this was not D3 but rather Calcifediol (a D3 metabolite), and a much smaller study.
- deleted 6y ago
  [deleted]
- Arech 6y ago
  There's nothing contradictory in it. It may take several months to restore normal Vitamin D level from the state of deficiency, so it's very long process. On average much longer than typical Covid duration. Proper Vitamin D level should be reached _before_ contact with the virus. Then the data would be valuable and helpful. Theirs data doesn't show much, imho.
adrianN 6y ago
"Treat it as if it were a preprint" is different from discounting the paper.
- neuronic 6y ago
  That's the science-snobby way of dismissing it.
  - adrianN 6y ago
    Not at all, preprints are very important because the publishing process can take many months. In fast moving fields (e.g. COVID research) working with preprints is vital if you want to do cutting edge research.

UShouldBWorking 6y ago

Also, an actual peer reviewed paper came out recently that showed giving vitamin d to covid patients upon admitting them did not decrease death rates. I'll look for the link but it was front page here like two weeks ago.

coding123 6y ago
Please find the link because about 2 / 3 months ago there was a story that was exactly the opposite finding. https://news.ycombinator.com/item?id=24366006 https://news.ycombinator.com/item?id=24366006 I've been monitoring HN for Vitamin D info very closely.
- zamfi 6y ago
  I think the parent poster is referring to https://www.medrxiv.org/content/10.1101/2020.11.16.20232397v1 https://www.medrxiv.org/content/10.1101/2020.11.16.20232397v... (Can't find the HN discussion link at the moment, unfortunately -- it didn't point to that particular link!) Worth noting that this RCT was for bolus supplementation of Vitamin D3 at some point in their hospital stay, and excluded patients already supplementing with D3. This study stands in stark contrast to the earlier pilot out of Spain: https://www.sciencedirect.com/science/article/pii/S0960076020302764?via%3Dihub#bib0100 https://www.sciencedirect.com/science/article/pii/S096007602... -- though as noted, this was not D3 but rather Calcifediol (a D3 metabolite), and a much smaller study.
deleted 6y ago
[deleted]
Arech 6y ago
There's nothing contradictory in it. It may take several months to restore normal Vitamin D level from the state of deficiency, so it's very long process. On average much longer than typical Covid duration. Proper Vitamin D level should be reached _before_ contact with the virus. Then the data would be valuable and helpful. Theirs data doesn't show much, imho.

adrianN 6y ago

"Treat it as if it were a preprint" is different from discounting the paper.

neuronic 6y ago
That's the science-snobby way of dismissing it.
- adrianN 6y ago
  Not at all, preprints are very important because the publishing process can take many months. In fast moving fields (e.g. COVID research) working with preprints is vital if you want to do cutting edge research.