4 ms·
If this was a correlation study I could agree with you but more accurately I would instead posit that no hypothesis is confirmed. But this is a study about a de
by ethn 6y ago
If this was a correlation study I could agree with you but more accurately I would instead posit that no hypothesis is confirmed. But this is a study about a deterministic mechanistic action.
We know that DMT binds with sigma-1 receptors (S1R) which is known to promote neurogenesis, such as fluvoxamine (in addition to many other SSRIs) in humans; we further know that the medication causes neurogenesis in humans, as do other medications with S1R affinity[0].
We then know that DMT does as well, we then measure that neurogenesis is observed in mice due to the same exact mechanism as SSRI's (i.e. medications with S1R affinity) in humans.
Perhaps at some point we should realize deterministic action in the context of the mammalian brain over human exceptionalism.
[0] https://pubmed.ncbi.nlm.nih.gov/20373470/ https://pubmed.ncbi.nlm.nih.gov/20373470/
- lambdaloop 6y agoThank you for the context! I looked briefly through the review that you cited. Maybe I missed something, but it seems that the neurogenesis claims are based on cell cultures? I'd still like to see some human evidence of this effect to be fully convinced, but still that this story fits in this broader context does help convince me that this is likely true in humans.
- a20eac1d 6y agoDo you know if Psilocybin causes the same or similar neurogenesis? And if it does, how?
- dave_sullivan 6y agoYes. DMT and psilocybin are structurally very similar. Try them both at the same time if you really want to see something wild.
- vanderZwan 6y agoMake sure you're on the ground floor though, and generally in a safe space with people you trust who can make sure you're alright. Just saying because one of my classmates in art school barely survived jumping out of a five story building due to a bad trip.