Partially inflate the tube after the tire is pulled aside, then run a mixture of soapy water over the tube. Sure, the tire is a bit in the way, but that is stil

Partially inflate the tube after the tire is pulled aside, then run a mixture of soapy water over the tube. Sure, the tire is a bit in the way, but that is still less hassle than removing the wheel. The only real danger is that the tube needs to be treated carefully to keep it from snagging on things and causing more damage.