> The drugs we are talking about are meant to effect a permanent change on the user. You'd only say someones judgement about themselves is unreliable if they

> The drugs we are talking about are meant to effect a permanent change on the user. You'd only say someones judgement about themselves is unreliable if they will contradict themselves later. But if it is a permanent change, then you are talking to the "new" person who is capable of judging this as well as anyone.