8 ms·

My 23andMe profile says I have a larger than average amount of Neanderthal DNA. How can I see if I have the risk factors in this study?

by iends 6y ago

jmnicolas 6y ago
I know a 65 yo woman who has diabetes, had a cancer and has cardiac problems. Her cardiologist told her "stay home, because if you get COVID you will die". She caught it in march or April, stayed in bed for 15 days. She fully recovered. I saw her this summer, if she didn't tell me I wouldn't have guessed she had it. So don't worry too much, even if you're a big risk death isn't guaranteed apparently ;)
- crankyoldcrank 6y ago
  Careful, you're starting to sound like a COVID denier. Next thing you'll know you'll be saying restaurants shouldn't be closed for a year and families should be allowed to gather for Thanksgiving! Say bye to your karma then
- bawolff 6y ago
  Obviously not. There is no 100% in probability in real life. That doesn't change the risk calculation.
- thombat 6y ago
  Some of the hedgehogs that bumble across the highway arrive safely at the other side.
  - boringg 6y ago
    Great expression.
  - jmnicolas 6y ago
    I'll let you search for the probabilities of dying from COVID VS edgehog highway crossing and determine if it's a fair comparison. My point was: don't live in fear.
    - thombat 6y ago
      But please do live in common sense and apply proportionate safeguards: when you notice a changed mole go to the dermatologist. When you cross the road look both ways first, even when you "know" there's nothing coming. And when you're living in a pandemic take sensible measures to reduce the risk to you, and especially to your fellow citizens. [belatedly saw your later remarks about Neanderthals] - agreed, this new info about genetic heritage doesn't itself warrant acute panic, but it's easy to seem glibly dismissive of all risk. Keep safe, and with luck your local medics will get enough rest that when you arrive at their doors with some non-COVID condition they'll be able to help.
- boringg 6y ago
  Lucky woman to fall in a high risk category and still live through it. I feel like I understand what you are saying but I would phrase it differently as your statement comes off a bit cavalier about the risk. I would say that while there is a lot of fear about COVID, and much of it justified on the mortality and long term effects that many people are suffering from, do not live in complete fear life can and will prevail. Be cautious on risk, where a mask for your benefits and to minimize the risk to your community etc. For me when I read your statement it almost comes across as a "well I got wasted and drove home drunk and made it home safely (not self driving vehicle FWIW), therefore I should always go home drunk and maybe advocate that my friends should try it to". Now I'm not saying thats what you are writing but it's a bit unclear.
- bleepblorp 6y ago
  What was your reason for posting this? Risk factors are about probabilities, not certainties. Anyone who has even rudimentary exposure to statistics will understand this. One single heartwarming anecdote does not invalidate the fact that the odds didn't work out for 1.4 million people world wide.
- thomastjeffery 6y ago
  So you are saying that her cardiologist was wrong in their recommendation? Why do you think that cardiologist made it in the first place? Is it possible that the cardiologist's prediction was sane even though it was wrong in this case?
  - jmnicolas 6y ago
    No what I'm saying is "don't live in fear", even the worse prognosis doesn't automatically leads to death.
    - thomastjeffery 6y ago
      What you are calling "living in fear" is a temporary circumstance that can prevent permanent consequence. Even if that consequence isn't guaranteed, it's worth the sacrifice to avoid it.
      - jmnicolas 6y ago
        We're not speaking of the same thing: you assume that by not living in fear I mean not taking any precautions. What I mean is don't fret over your Neanderthal great great [...] grandpa that might transmitted you a bad gene for COVID.
        thomastjeffery 6y ago
        > We're not speaking of the same thing: you assume that by not living in fear I mean not taking any precautions. I'm only going off of what you said: > "don't live in fear", even the worse prognosis doesn't automatically leads to death. > So don't worry too much, even if you're a big risk death isn't guaranteed apparently ;) It's pretty clear to me that you are saying that we shouldn't try to avoid catching COVID-19, even though it presents a significant mortal risk, because that would be "living in fear". At least, that is what you were saying until your most recent comment. > What I mean is don't fret over your Neanderthal great great [...] grandpa that might transmitted you a bad gene for COVID. I mean, you could have said that in the first place. Instead, you brought up a story about a woman who had cardiac problems, which totally shifted the conversation away from Neanderthal DNA. If the story you brought up was supposed to be an allegory for people worrying about Neanderthal DNA, then there are a couple things to consider: 1. No one is equating Neanderthal DNA to cardiac disease as a risk factor for COVID-19 mortality. 2. Choosing not to worry about cardiac disease as a risk factor for COVID-19 mortality is clearly a bad idea, even if some people with cardiac disease don't die to COVID-19.
sjg007 6y ago
Are you blood type A or AB? If so you have a high risk.
- DoreenMichele 6y ago
  Your comment initially said "type A" only. Can you provide a citation? Because a quick google isn't really agreeing with that: https://www.nature.com/articles/s41467-020-19623-x https://www.nature.com/articles/s41467-020-19623-x (I'm not trying to be a jerk. I'm about to rush out the door, haven't had enough sleep and I think if we know something about what blood types are impacted, that's useful info.)
  - sjg007 6y ago
    https://www.hematology.org/newsroom/press-releases/2020/possible-link-between-blood-type-and-covid-19 https://www.hematology.org/newsroom/press-releases/2020/poss...
    - martinpw 6y ago
      Your "high risk" comment seems like an overstatement. That press release does not give any actual numbers, but links to two studies. I quickly scanned the studies, so may have missed something, but the Denmark one seems to indicate a ~10% higher risk for A/AB than O. While statistically significant, it does not seem like a massive difference. Also, importantly, it states: This study identifies ABO blood group as a risk factor for SARS-CoV-2 infection but not for hospitalization or death from COVID-19.
      - sjg007 6y ago
        It's more serious than that. The caveat is "if hospitalized".
mmcconnell1618 6y ago
Looks like for some 23andme customer, you can go to the Raw Data under your account and search for rs10490770. If that has the "C" variant, then you are almost certain to have the "G" variant of rs35044562 which puts you into the higher risk covid group. (don't take anything here as medical advice, just digging into the data to see if you can find out something helpful). https://www.wikitree.com/g2g/1067199/new-clinical-study-links-covid-effect-particular-dna-segment https://www.wikitree.com/g2g/1067199/new-clinical-study-link... "A new genome-wide association study has identified a section of chromosome 3 where particular alleles are associated with severed effects after COVID_19 infection. This was then confirmed by a clinical trial of patients. The reported risk SNPs are having Cytosine (C) at position rs10490770 and Guanine (G) at rs35044562. These are in "full linkage disequilibrium", meaning if you have C at the first spot then you almost certainly have G at the second. And you can now check for C at rs10490770 in some 23andMe, Family Finder, and Ancestry raw data files, or directly on 23andMe using Browse Raw Data. You can search for rs10490770 in your or other people's 23andMe v2,v3,v4, Family Finder and MyHeritage v1, or Ancestry v1,v2 raw data. It's not on the GSA chip, and therefore not on 23andMe v5, FTDNA v2, or MyHeritage v2. It is on Ancestry v1 and v2." So you can search your 23andMe data for rs10490770 by going to https://you.23andme.com/tools/data/ https://you.23andme.com/tools/data/ More information and options are at https://customercare.23andme.com/hc/en-us/articles/115004310067-Navigating-Your-Raw-Data https://customercare.23andme.com/hc/en-us/articles/115004310...

My 23andMe profile says I have a larger than average amount of Neanderthal DNA. How can I see if I have the risk factors in this study?

by iends 6y ago

My 23andMe profile says I have a larger than average amount of Neanderthal DNA. How can I see if I have the risk factors in this study?

jmnicolas 6y ago

I know a 65 yo woman who has diabetes, had a cancer and has cardiac problems. Her cardiologist told her "stay home, because if you get COVID you will die". She caught it in march or April, stayed in bed for 15 days. She fully recovered. I saw her this summer, if she didn't tell me I wouldn't have guessed she had it. So don't worry too much, even if you're a big risk death isn't guaranteed apparently ;)

crankyoldcrank 6y ago
Careful, you're starting to sound like a COVID denier. Next thing you'll know you'll be saying restaurants shouldn't be closed for a year and families should be allowed to gather for Thanksgiving! Say bye to your karma then
bawolff 6y ago
Obviously not. There is no 100% in probability in real life. That doesn't change the risk calculation.
thombat 6y ago
Some of the hedgehogs that bumble across the highway arrive safely at the other side.
- boringg 6y ago
  Great expression.
- jmnicolas 6y ago
  I'll let you search for the probabilities of dying from COVID VS edgehog highway crossing and determine if it's a fair comparison. My point was: don't live in fear.
  - thombat 6y ago
    But please do live in common sense and apply proportionate safeguards: when you notice a changed mole go to the dermatologist. When you cross the road look both ways first, even when you "know" there's nothing coming. And when you're living in a pandemic take sensible measures to reduce the risk to you, and especially to your fellow citizens. [belatedly saw your later remarks about Neanderthals] - agreed, this new info about genetic heritage doesn't itself warrant acute panic, but it's easy to seem glibly dismissive of all risk. Keep safe, and with luck your local medics will get enough rest that when you arrive at their doors with some non-COVID condition they'll be able to help.
boringg 6y ago
Lucky woman to fall in a high risk category and still live through it. I feel like I understand what you are saying but I would phrase it differently as your statement comes off a bit cavalier about the risk. I would say that while there is a lot of fear about COVID, and much of it justified on the mortality and long term effects that many people are suffering from, do not live in complete fear life can and will prevail. Be cautious on risk, where a mask for your benefits and to minimize the risk to your community etc. For me when I read your statement it almost comes across as a "well I got wasted and drove home drunk and made it home safely (not self driving vehicle FWIW), therefore I should always go home drunk and maybe advocate that my friends should try it to". Now I'm not saying thats what you are writing but it's a bit unclear.
bleepblorp 6y ago
What was your reason for posting this? Risk factors are about probabilities, not certainties. Anyone who has even rudimentary exposure to statistics will understand this. One single heartwarming anecdote does not invalidate the fact that the odds didn't work out for 1.4 million people world wide.
thomastjeffery 6y ago
So you are saying that her cardiologist was wrong in their recommendation? Why do you think that cardiologist made it in the first place? Is it possible that the cardiologist's prediction was sane even though it was wrong in this case?
- jmnicolas 6y ago
  No what I'm saying is "don't live in fear", even the worse prognosis doesn't automatically leads to death.
  - thomastjeffery 6y ago
    What you are calling "living in fear" is a temporary circumstance that can prevent permanent consequence. Even if that consequence isn't guaranteed, it's worth the sacrifice to avoid it.
    - jmnicolas 6y ago
      We're not speaking of the same thing: you assume that by not living in fear I mean not taking any precautions. What I mean is don't fret over your Neanderthal great great [...] grandpa that might transmitted you a bad gene for COVID.
      - thomastjeffery 6y ago
        > We're not speaking of the same thing: you assume that by not living in fear I mean not taking any precautions. I'm only going off of what you said: > "don't live in fear", even the worse prognosis doesn't automatically leads to death. > So don't worry too much, even if you're a big risk death isn't guaranteed apparently ;) It's pretty clear to me that you are saying that we shouldn't try to avoid catching COVID-19, even though it presents a significant mortal risk, because that would be "living in fear". At least, that is what you were saying until your most recent comment. > What I mean is don't fret over your Neanderthal great great [...] grandpa that might transmitted you a bad gene for COVID. I mean, you could have said that in the first place. Instead, you brought up a story about a woman who had cardiac problems, which totally shifted the conversation away from Neanderthal DNA. If the story you brought up was supposed to be an allegory for people worrying about Neanderthal DNA, then there are a couple things to consider: 1. No one is equating Neanderthal DNA to cardiac disease as a risk factor for COVID-19 mortality. 2. Choosing not to worry about cardiac disease as a risk factor for COVID-19 mortality is clearly a bad idea, even if some people with cardiac disease don't die to COVID-19.

sjg007 6y ago

Are you blood type A or AB? If so you have a high risk.

DoreenMichele 6y ago
Your comment initially said "type A" only. Can you provide a citation? Because a quick google isn't really agreeing with that: https://www.nature.com/articles/s41467-020-19623-x https://www.nature.com/articles/s41467-020-19623-x (I'm not trying to be a jerk. I'm about to rush out the door, haven't had enough sleep and I think if we know something about what blood types are impacted, that's useful info.)
- sjg007 6y ago
  https://www.hematology.org/newsroom/press-releases/2020/possible-link-between-blood-type-and-covid-19 https://www.hematology.org/newsroom/press-releases/2020/poss...
  - martinpw 6y ago
    Your "high risk" comment seems like an overstatement. That press release does not give any actual numbers, but links to two studies. I quickly scanned the studies, so may have missed something, but the Denmark one seems to indicate a ~10% higher risk for A/AB than O. While statistically significant, it does not seem like a massive difference. Also, importantly, it states: This study identifies ABO blood group as a risk factor for SARS-CoV-2 infection but not for hospitalization or death from COVID-19.
    - sjg007 6y ago
      It's more serious than that. The caveat is "if hospitalized".

mmcconnell1618 6y ago

Looks like for some 23andme customer, you can go to the Raw Data under your account and search for rs10490770. If that has the "C" variant, then you are almost certain to have the "G" variant of rs35044562 which puts you into the higher risk covid group. (don't take anything here as medical advice, just digging into the data to see if you can find out something helpful). https://www.wikitree.com/g2g/1067199/new-clinical-study-links-covid-effect-particular-dna-segment https://www.wikitree.com/g2g/1067199/new-clinical-study-link... "A new genome-wide association study has identified a section of chromosome 3 where particular alleles are associated with severed effects after COVID_19 infection. This was then confirmed by a clinical trial of patients. The reported risk SNPs are having Cytosine (C) at position rs10490770 and Guanine (G) at rs35044562. These are in "full linkage disequilibrium", meaning if you have C at the first spot then you almost certainly have G at the second. And you can now check for C at rs10490770 in some 23andMe, Family Finder, and Ancestry raw data files, or directly on 23andMe using Browse Raw Data. You can search for rs10490770 in your or other people's 23andMe v2,v3,v4, Family Finder and MyHeritage v1, or Ancestry v1,v2 raw data. It's not on the GSA chip, and therefore not on 23andMe v5, FTDNA v2, or MyHeritage v2. It is on Ancestry v1 and v2." So you can search your 23andMe data for rs10490770 by going to https://you.23andme.com/tools/data/ https://you.23andme.com/tools/data/ More information and options are at https://customercare.23andme.com/hc/en-us/articles/115004310067-Navigating-Your-Raw-Data https://customercare.23andme.com/hc/en-us/articles/115004310...