3 ms·

Which psychedelics (shrooms, acid, peyote, salvia, ketamine, ayahuasca) would be best for endogenous, treatment-resistant depression? If there are any with a p

Which psychedelics (shrooms, acid, peyote, salvia, ketamine, ayahuasca) would be best for endogenous, treatment-resistant depression? If there are any with a proven effect, do they have to be taken periodically?

3np 6y ago
Ketamine is not generally considered a psychedelic. It's a disassociative. I don't think I've ever seen a study comparing this in the way you describe, but from piecing together other papers I recall seeing I would say probably psiloc(yb)in, possibly DMT ("ayahuasca"), with LSD and mescaline (peyote/san pedro) being qualitatively similar. All of these are primarily serotonergic. I'd be surprised if Salvia does jack shit in that domain, regardless of how trippy the experience can be. It acts very differently.
- lostgame 6y ago
  >> Ketamine is not generally considered a psychedelic. It's a disassociative. Yeah, I don't think people who say that have done a high enough dosage. :P
  - 3np 6y ago
    It can absolutely induce psychedelic experiences - in medical literature it's not generally (though this is not entirely consistent) classified as a psychedelic.
  - drooogs 6y ago
    kinda splitting hairs, but these words do have specific meanings. psychedelics and dissociatives of hallucinogens, a broader category of drugs. you definitely see weird stuff if you take enough ketamine, but the hallucinations have a very different character. subjectively, I find psychedelics to have more of an "organic" feel and dissociatives to have a more "synthetic" feel, although I imagine others might describe it differently.
- blkknightarms 6y ago
  True. I should've called it a list of psychoactives.
turrini 6y ago
Ayahuasca changed my life completely, for the better. I went from years of depression to zero depression in the first profound session. And I'm not a religious guy. I highly recommend.
- abyssin 6y ago
  I'd love to read your story. Did you write about it? The years of depression, traveling to the ayahuasca place, the sessions, the changes you made in your life afterwards.
  - turrini 6y ago
    I intend to write about it soon in the coming weeks and I will post my life changing experience here, for sure!
zer0tonin 6y ago
Ketamine is now a FDA-approved treatment for depression / suicidal ideation.
temp0826 6y ago
(Speaking for tryptamines as I’m not to sure about the others). It might require periodic doses until you actually resolve your trauma, which more often than not takes a lot of uncomfortable digging. It’s typical to spend at least a couple of weeks at an ayahuasca retreat, drinking several times throughout the stay. In my experience, unless you’re somewhat lucky, won’t have that life changing experience on your first session.

3np 6y ago

Ketamine is not generally considered a psychedelic. It's a disassociative. I don't think I've ever seen a study comparing this in the way you describe, but from piecing together other papers I recall seeing I would say probably psiloc(yb)in, possibly DMT ("ayahuasca"), with LSD and mescaline (peyote/san pedro) being qualitatively similar. All of these are primarily serotonergic. I'd be surprised if Salvia does jack shit in that domain, regardless of how trippy the experience can be. It acts very differently.

lostgame 6y ago
>> Ketamine is not generally considered a psychedelic. It's a disassociative. Yeah, I don't think people who say that have done a high enough dosage. :P
- 3np 6y ago
  It can absolutely induce psychedelic experiences - in medical literature it's not generally (though this is not entirely consistent) classified as a psychedelic.
- drooogs 6y ago
  kinda splitting hairs, but these words do have specific meanings. psychedelics and dissociatives of hallucinogens, a broader category of drugs. you definitely see weird stuff if you take enough ketamine, but the hallucinations have a very different character. subjectively, I find psychedelics to have more of an "organic" feel and dissociatives to have a more "synthetic" feel, although I imagine others might describe it differently.
blkknightarms 6y ago
True. I should've called it a list of psychoactives.

turrini 6y ago

Ayahuasca changed my life completely, for the better. I went from years of depression to zero depression in the first profound session. And I'm not a religious guy. I highly recommend.

abyssin 6y ago
I'd love to read your story. Did you write about it? The years of depression, traveling to the ayahuasca place, the sessions, the changes you made in your life afterwards.
- turrini 6y ago
  I intend to write about it soon in the coming weeks and I will post my life changing experience here, for sure!

zer0tonin 6y ago

Ketamine is now a FDA-approved treatment for depression / suicidal ideation.

temp0826 6y ago

(Speaking for tryptamines as I’m not to sure about the others). It might require periodic doses until you actually resolve your trauma, which more often than not takes a lot of uncomfortable digging. It’s typical to spend at least a couple of weeks at an ayahuasca retreat, drinking several times throughout the stay. In my experience, unless you’re somewhat lucky, won’t have that life changing experience on your first session.