2 ms·

>On the other hand, the ribosome is an amazingly complex machine Just a bit: Transcription - https://www.youtube.com/watch?v=SMtWvDbfHLo https://www.youtube.c

by jcims 6y ago

>On the other hand, the ribosome is an amazingly complex machine Just a bit: Transcription - https://www.youtube.com/watch?v=SMtWvDbfHLo https://www.youtube.com/watch?v=SMtWvDbfHLo Translation - https://www.youtube.com/watch?v=TfYf_rPWUdY https://www.youtube.com/watch?v=TfYf_rPWUdY Replication - https://www.youtube.com/watch?v=I9ArIJWYZHI https://www.youtube.com/watch?v=I9ArIJWYZHI It's not clear to me how much these features can be degraded without destroying the ability for organisms to reproduce with heritable traits. Also, when listening to these videos, ask yourself 'how' and 'why' any time an action is described. For example, the following parenthetical questions from a small chunk of the 'Translation' video: "The addition of each amino acid is a three-step cycle; (Why three step?) First the tRNA enters the ribosome at the A-Site (Why does it only enter at the A-Site? How are other options prevented and/or made inconsequential? Was it always this way? How did the features of the A-Site evolve for this to happen. What happened before this? ), and is tested for a codon / anti-codon match with the mRNA. (How is the tRNA tested? What happens when it fails the test or is missing the amino acid? What is the energy budget of this test and what are the specific features of the ribosome, RNA, tRNA and amino acid that make it possible? What happened before this testing was done? How did we get from the lack of ability to test and the ability to test?) Next, provided there is a correct match, the tRNA is shifted to the P-Site (What is the mechanism of this shifting? Why does it only go one direction? What is the energy budget of this process and how is it powered? How do we prevent multiple tRNA from shifting or keep it from shifting more than one spot? What occurred before the ribosome/RNA/tRNA/amino-acid had the features to allow this to occur?)" You get the idea.

deleted 6y ago
[deleted]
pontifier 6y ago
The systems are very complex, but what I see is a few active sites and a bunch of random stuff that happens to hold them in the right spots to control them a bit. When reasoning from first principals about immune response, it occured to me that just a few simple processes might be all that is required to explore novel active structures in an organism. Based partly on my understanding of a study of bacteria that evolved the ability to metabolise a new nutrient, a mutation prior to use is required. The ability to detect a molecule might evolve based on immune responses that use random sequences as "test" active sites that are checked for a specific type of deformation. If this random sequence deforms immediately, it is discarded because this sequence either deforms automatically or deforms in the presence of something common to "host". If the test remains negative it is released from the host training environment. If the test pattern deforms some time later, it has detected a "foreign" molecule, and has the potential for use as part of a protein that manipulates this molecule. Recovering the sequence that detects this new foreign molecule becomes the first step in a hereditary immunity. It also stores this useful sequence for possible use in other "testing" systems. These might bring 3 or 4 of these random test systems together to perform another test. Simple systems that explore a complex space can come up with seemingly elegant solutions. The most obvious answer to any of your questions is that, if it worked a different way, that's what the video would show... or there would be no video at all.

by jcims 6y ago

deleted 6y ago

[deleted]

pontifier 6y ago

The systems are very complex, but what I see is a few active sites and a bunch of random stuff that happens to hold them in the right spots to control them a bit. When reasoning from first principals about immune response, it occured to me that just a few simple processes might be all that is required to explore novel active structures in an organism. Based partly on my understanding of a study of bacteria that evolved the ability to metabolise a new nutrient, a mutation prior to use is required. The ability to detect a molecule might evolve based on immune responses that use random sequences as "test" active sites that are checked for a specific type of deformation. If this random sequence deforms immediately, it is discarded because this sequence either deforms automatically or deforms in the presence of something common to "host". If the test remains negative it is released from the host training environment. If the test pattern deforms some time later, it has detected a "foreign" molecule, and has the potential for use as part of a protein that manipulates this molecule. Recovering the sequence that detects this new foreign molecule becomes the first step in a hereditary immunity. It also stores this useful sequence for possible use in other "testing" systems. These might bring 3 or 4 of these random test systems together to perform another test. Simple systems that explore a complex space can come up with seemingly elegant solutions. The most obvious answer to any of your questions is that, if it worked a different way, that's what the video would show... or there would be no video at all.