For some reason large doses of mushroom generally soothe my body because I tend to relax during and after the trip, but small doses (typical microdose scales) c

For some reason large doses of mushroom generally soothe my body because I tend to relax during and after the trip, but small doses (typical microdose scales) cause me to have quite severe headaches. Not migraine-levels of pain, but leave work and go lay down kind of pain. I wonder what that mechanism is. Why not worse headaches, or any headaches with large doses? Why would such a tiny amount cause so much pain? Has anyone here experienced anything similar? It's a shame because I enjoy the glow of microdoses prior to the delayed onset of the headache. I don't feel anything remotely like a trip, but I do feel a sort of positivity and warmth I otherwise wouldn't. Almost like my mind has slowed down to take a break, and as a result, it feels a little nicer.