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In case anybody was wondering what this actually is: “The ChAdOx1 vaccine is a chimpanzee adenovirus vaccine vector.” They put a corona spike sequence into it.
by jl2718 6y ago
In case anybody was wondering what this actually is: “The ChAdOx1 vaccine is a chimpanzee adenovirus vaccine vector.” They put a corona spike sequence into it.
By comparison, the Moderna is making a RNA vaccine, and BioNTech an epitope vaccine (the actual protein).
The ‘invasive’ effect is decreasing in that order. Oxford’s ChAdOx1 infects your cells to create RNA, then protein, then T-cell recognition/apoptosis, then epitopes trigger B-cell antibody production. Moderna RNA skips the infection part. BioNTech epitopes go right to B-cells.
But, they also have deceasing stability and manufacturing scalability in that order.
- xuhu 6y agoQuite a typo in your last sentence.
- jl2718 6y agoHa! I’m leaving it.
- thehappypm 6y agoBioNTech / Pfizer is also mRNA.
- rrss 6y ago> BioNTech an epitope vaccine I think BioNTech's vaccine is also an mRNA vaccine. https://biontech.de/covid-19 https://biontech.de/covid-19 > Our vaccine consists of a short segment of genetic material, called messenger RNA, that provides instructions for a human cell to make a harmless version of a target protein, or immunogen, which activates the body’s immune response against the SARS-CoV-2 virus https://en.wikipedia.org/wiki/BNT162b2 https://en.wikipedia.org/wiki/BNT162b2
- jl2718 6y agoOh interesting. I’ve been following their cancer neo-epitope vaccine research and didn’t notice this was a different process.
- shmageggy 6y agoThanks for the additional context. This is interesting because the has been some worry about the safety of the new and relatively untested mRNA technology, but this makes it seem like traditional vaccines are just that with extra steps. Should that be a license to feel safer about mRNA?
- jl2718 6y agoWell I think it suggests a hypothesis for its safety, but real effects are hard to predict in such a complex system.