3 ms·

Is there possible explanation why would first half dose have much better results than full dose?

• pessimist 6y ago
  This vaccine is an inactive host virus whose payload has been replaced by the coronavirus "spike". It has always been a worry that the body will generate immunity to the host virus and thus make the vaccine less effective. That is a likely explanation for the first-full-dose regimen being less effective.
  • aquadrop 6y ago
    Shouldn't it warrant a research if even smaller dose has even higher efficiency?
    • pessimist 6y ago
      Yes. But clinical trials are expensive ($100m plus) and time consuming.
      • _Gyan_ 6y ago
        If both regimens underwent Phase 2 testing, there should be data on comparative immunogenicity.
• bluGill 6y ago
  Statistical factors: the sample size is so small that it could be less effective and still show up this much more effective. I hope not, but sadly it is a real possibility that needs further study.