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Is there any research or early guestimates about risks (or benefits) of getting multiple different vaccines for Covid? E.g. What if one gets this, and then late

by rixrax 6y ago

Is there any research or early guestimates about risks (or benefits) of getting multiple different vaccines for Covid? E.g. What if one gets this, and then later moderna vaccine? Will they fight each other, or work together or is it unknown whats going to happen?

kuu 6y ago
>Will they fight each other, or work together I'm not a microbiologist, but this is not how vaccines work. The vaccines are going to put "something strange" in your body that "resembles" the virus, but it's not the virus (it's either a deactivated version of it, or some proteins which identify it...) and then is YOUR immune system the one which "attacks" this pseudo-virus. In this way, your immune system is learning how to defend to "this kind" of strange agents. In a future if your immune system sees the virus, will defend you. If you get the two kinds at the same time, maybe the two doses are too much for your immune system to handle it properly and the side effects may affect you (e.g. you can get fever because your immune system is under too heavy load).
- FriendlyNormie 6y ago
  Thanks for shedding light on the subject by sharing your 3rd grade elementary school understanding of how vaccines work. What would we do without you and your brilliant insights.
- hutzlibu 6y ago
  Most of the vaccines developed seem to work pretty much the same, by targeting the same spike protein. And I am also far from being a microbiologist either, but I do know that the immune system is very complex, so I would not rule anything out, when messing with it. In any case, getting the vaccination can (maybe) actually increase your risk of a severe Covid sickness, when you are exposed to real covid virus at the same time. https://onlinelibrary.wiley.com/doi/10.1111/ijcp.13795 https://onlinelibrary.wiley.com/doi/10.1111/ijcp.13795 And I have no data for it and I can imagine it being hard to get reliable data about it, but autoimmune sickness is on the rise. I am not sure a quickly hacked together vaccine can rule that possibility out.
- djmips 6y ago
  "In the future your immune system may help the virus." I think they tested for this in the Oxford vaccine but there is an interesting case such as in Dengue where in a subsequent infection you may do worse with antibodies present. https://en.wikipedia.org/wiki/Antibody-dependent_enhancement https://en.wikipedia.org/wiki/Antibody-dependent_enhancement
twic 6y ago
I'm not aware of any risks. There are definitely benefits to vaccine diversity. The Oxford ChAdOx1 virus involves putting a modified chimp adenovirus into people. People don't have immunity to chimp adenovirus, so it infects them and delivers the spike protein, which elicits immunity. But that might also elicit immunity to the chimp adenovirus! If that happens, then a later does of the vaccine - say, for a new strain of SARS-CoV-2 in a year or two - might not be as effective, because immunity to the chimp adenovirus will stop the vaccine delivering the spike. In that case, having a different way to deliver a vaccine will be a life-saver.
- jashephe 6y ago
  Indeed. Maybe someone with more expertise can chime in — it's not clear to me if getting a vaccine with the chimp adenovirus backbone would preclude the possibility of getting another vaccine based on that backbone in the future (because of immunity to the backbone).

by rixrax 6y ago

kuu 6y ago

>Will they fight each other, or work together I'm not a microbiologist, but this is not how vaccines work. The vaccines are going to put "something strange" in your body that "resembles" the virus, but it's not the virus (it's either a deactivated version of it, or some proteins which identify it...) and then is YOUR immune system the one which "attacks" this pseudo-virus. In this way, your immune system is learning how to defend to "this kind" of strange agents. In a future if your immune system sees the virus, will defend you. If you get the two kinds at the same time, maybe the two doses are too much for your immune system to handle it properly and the side effects may affect you (e.g. you can get fever because your immune system is under too heavy load).

FriendlyNormie 6y ago
Thanks for shedding light on the subject by sharing your 3rd grade elementary school understanding of how vaccines work. What would we do without you and your brilliant insights.
hutzlibu 6y ago
Most of the vaccines developed seem to work pretty much the same, by targeting the same spike protein. And I am also far from being a microbiologist either, but I do know that the immune system is very complex, so I would not rule anything out, when messing with it. In any case, getting the vaccination can (maybe) actually increase your risk of a severe Covid sickness, when you are exposed to real covid virus at the same time. https://onlinelibrary.wiley.com/doi/10.1111/ijcp.13795 https://onlinelibrary.wiley.com/doi/10.1111/ijcp.13795 And I have no data for it and I can imagine it being hard to get reliable data about it, but autoimmune sickness is on the rise. I am not sure a quickly hacked together vaccine can rule that possibility out.
djmips 6y ago
"In the future your immune system may help the virus." I think they tested for this in the Oxford vaccine but there is an interesting case such as in Dengue where in a subsequent infection you may do worse with antibodies present. https://en.wikipedia.org/wiki/Antibody-dependent_enhancement https://en.wikipedia.org/wiki/Antibody-dependent_enhancement

twic 6y ago

I'm not aware of any risks. There are definitely benefits to vaccine diversity. The Oxford ChAdOx1 virus involves putting a modified chimp adenovirus into people. People don't have immunity to chimp adenovirus, so it infects them and delivers the spike protein, which elicits immunity. But that might also elicit immunity to the chimp adenovirus! If that happens, then a later does of the vaccine - say, for a new strain of SARS-CoV-2 in a year or two - might not be as effective, because immunity to the chimp adenovirus will stop the vaccine delivering the spike. In that case, having a different way to deliver a vaccine will be a life-saver.

jashephe 6y ago
Indeed. Maybe someone with more expertise can chime in — it's not clear to me if getting a vaccine with the chimp adenovirus backbone would preclude the possibility of getting another vaccine based on that backbone in the future (because of immunity to the backbone).