3 ms·
Does anyone here who understands vaccines know how starting with a smaller does can improve effectiveness? It goes against my intuition.
by skrebbel 6y ago
Does anyone here who understands vaccines know how starting with a smaller does can improve effectiveness? It goes against my intuition.
- BillyTheKing 6y agoI wonder what the statistical significance is of those findings. I seems to me that they tried out various different approaches, so the sub-group that received this first-low-second-high treatment might be considerably smaller than the other groups combined leading to slightly less certainty in regards to the findings.
- wbl 6y agoThis vaccine is a viral vector vaccine. Immunity against the vector can be an issue, but this is moderately informed speculation.
- ulfw 6y agoBut it's a chimpanzee vector. Not a human one.
- freeone3000 6y agoHumans can develop an immune response to things that are not infectious to humans.