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> chamber inducing a state of hypoxia, or oxygen shortage, which caused the cell regeneration. Might actually be related to life extension through calorie rest

> chamber inducing a state of hypoxia, or oxygen shortage, which caused the cell regeneration. Might actually be related to life extension through calorie restriction in this regard. This paper re calories restriction mentions: > caloric restriction improves whole body energy efficiency by inducing the biogenesis of mitochondria that utilize less oxygen and produce less reactive oxygen species (ROS). https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.0040076 https://journals.plos.org/plosmedicine/article?id=10.1371/jo... Starving the body of oxygen might trigger some of the same genetic pathways as starving it of food, basically.

vsareto 6y ago
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901353/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901353/ I thought the free radical/antioxidant stuff was done with?
- lnanek2 6y ago
  The calorie restriction one says: > increased expression of genes encoding proteins involved in mitochondrial function such as PPARGC1A, TFAM, eNOS, SIRT1, and PARL Meanwhile SIRT1 has been proven to be life extending via genetically engineering mice to have it: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291425/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291425/ So the claim of https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901353/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901353/ that this is just shifting damage from one type of damage to another and can't prolong life doesn't seem to hold water.