5 ms·

Obesity lowers serum concentrations of Vitamin-D. We know obesity is strongly correlated with severe covid. So not really that interesting of a correlation IM

Obesity lowers serum concentrations of Vitamin-D. We know obesity is strongly correlated with severe covid. So not really that interesting of a correlation IMO.

gfodor 6y ago
Any correlation where one can change one of the variables by taking a cheap, safe pill is interesting, unless we can show which way the causality goes.
- anonuser123456 6y ago
  Well... taking that cheap pill in a blind RCT would show the arrow of causality. People have known about this correlation for months now. If it were really a thing, clinicians would be publishing case studies like crazy of successful treatment with vitamin-D. I'm not seeing that in the literature... so I doubt it will pan out.
  - oieoeireoes 6y ago
    I also wouldn't expect much from giving D3 in a hospital setting since it takes time for D3 supplementation to affect serum levels. That's why the MATH+ protocol [1] recommends Calcifediol or Cholecalciferol. According to their own review [2] the protocol reduces hospital mortality from 20-30% to about 5%. [1]: https://covid19criticalcare.com/math-hospital-treatment/pdf-translations/ https://covid19criticalcare.com/math-hospital-treatment/pdf-... [2]: https://covid19criticalcare.com/math-hospital-treatment/scientific-review-of-covid-19-and-math-plus/ https://covid19criticalcare.com/math-hospital-treatment/scie...
    - geomark 6y ago
      Tangential question: How long does it take exposure to sunlight to affect serum levels?
      - kevinmchugh 6y ago
        Depends on latitude, season, and melanin, as I understand it
oieoeireoes 6y ago
Yes, D is fat-soluble, so it won't increase much in serum levels until the fat is saturated with it. But your criticism doesn't necessarily check out as the average BMI of group B was actually lower than that of group A. See page 4 of the PDF [1]. [1]: https://www.nature.com/articles/s41598-020-77093-z.pdf https://www.nature.com/articles/s41598-020-77093-z.pdf

Obesity lowers serum concentrations of Vitamin-D. We know obesity is strongly correlated with severe covid. So not really that interesting of a correlation IMO.

gfodor 6y ago

Any correlation where one can change one of the variables by taking a cheap, safe pill is interesting, unless we can show which way the causality goes.

anonuser123456 6y ago
Well... taking that cheap pill in a blind RCT would show the arrow of causality. People have known about this correlation for months now. If it were really a thing, clinicians would be publishing case studies like crazy of successful treatment with vitamin-D. I'm not seeing that in the literature... so I doubt it will pan out.
- oieoeireoes 6y ago
  I also wouldn't expect much from giving D3 in a hospital setting since it takes time for D3 supplementation to affect serum levels. That's why the MATH+ protocol [1] recommends Calcifediol or Cholecalciferol. According to their own review [2] the protocol reduces hospital mortality from 20-30% to about 5%. [1]: https://covid19criticalcare.com/math-hospital-treatment/pdf-translations/ https://covid19criticalcare.com/math-hospital-treatment/pdf-... [2]: https://covid19criticalcare.com/math-hospital-treatment/scientific-review-of-covid-19-and-math-plus/ https://covid19criticalcare.com/math-hospital-treatment/scie...
  - geomark 6y ago
    Tangential question: How long does it take exposure to sunlight to affect serum levels?
    - kevinmchugh 6y ago
      Depends on latitude, season, and melanin, as I understand it

oieoeireoes 6y ago

Yes, D is fat-soluble, so it won't increase much in serum levels until the fat is saturated with it. But your criticism doesn't necessarily check out as the average BMI of group B was actually lower than that of group A. See page 4 of the PDF [1]. [1]: https://www.nature.com/articles/s41598-020-77093-z.pdf https://www.nature.com/articles/s41598-020-77093-z.pdf