Yes, in fact it's pretty easy. You just add the right arguments to GRUB, though I don't remember them off-hand. I used to have a flash drive with GRUB installe

Yes, in fact it's pretty easy. You just add the right arguments to GRUB, though I don't remember them off-hand. I used to have a flash drive with GRUB installed, and several "Live CD" ISOs. It would have two options per ISO: the second would copy the squashfs to a ramdisk before boot. Tinycore is especially great when you don't have USB3 available, because you don't have to wait minutes for >1GB of data to be copied to RAM.