5 ms·

Human ageing process biologically reversed in world first

21 points by huntermeyer 6y ago

chris-orgmenta 6y ago
- "The pressurised chamber allows more oxygen to be dissolved into the tissues and mimics a state of "hypoxia", or oxygen shortage, which is known to have regenerating effects." This seems counter intuitive, anyone know the mechanism here? - Did this article fail to link the paper, or am I failing to see the link? Poor reporting if the former. - There is a gap in reporting here...anyone know exactly how telemeres actually lengthen from this? - Unrelated: Is anyone in the industry actually interested by Brett Weinstein's supposed involvement in lab mice telemere issue discovery, or is he seen as an irrelevant pest within these circles?
- tisu32 6y ago
  I found the article independently, linked on this reddit thread: https://www.reddit.com/r/longevity/comments/jwnqvu/aging_hyperbaric_oxygen_therapy_increases/ https://www.reddit.com/r/longevity/comments/jwnqvu/aging_hyp...
  - chris-orgmenta 6y ago
    Ah thank you. Shame - Red flags throughout that paper, albeit some being self identified.
tisu32 6y ago
From what I can tell as a complete layman, the title is quite sensationalist: the only process being reversed is telomere lengthening, which has a tenuous relationship with aging at best.
- pmdulaney 6y ago
  Yes, if researchers had really reversed human ageing, do you really think yahoo.com would be breaking the news?
  - lern_too_spel 6y ago
    I don't see what relevance that has to this story. Yahoo.com isn't breaking the news, only reporting about an article published in a journal.
    - pmdulaney 6y ago
      Yeah, you're right. I realized it was a dumb comment after I posted it...
- ksaj 6y ago
  I've actually studied this, and I agree with you. I see a notable difference between "less disease of a very specific sort" and "reversed aging" although the end result is remarkably similar (without the age digression, of course). The article treats them as the same. Unless your sole definition of aging is in re how far down the chain your telomerase shows up. To me, reversing aging would be more like the Benjamin Button story. But that's not the story being told here. Depending on how you are looking at it, they're either very similar things, or completely different things. I see them as being very different.
JoshuaDavid 6y ago
I was unable to find the paper the article claims was published about this, which is a shame because I'd love to learn more about what the researchers actually said. The mechanism described in the Yahoo article is implausible to say the least (TANSTAFFL principle: if you could reverse aging by simply lengthening telomeres, there would have been significant evolutionary pressure for increased expression of telomerase, so unless it came with sufficiently bad downsides, you would expect it to have already reached fixation in the population). Still, I would be interested to see what the researchers themselves actually say. I did find a related article, titled "Telomere elongation followed by telomere length reduction, in leukocytesfrom divers exposed to intense oxidative stress – Implications for tissueand organismal aging" [1]. I would expect the actual findings here were similar to that article. [1] http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.208.4475&rep=rep1&type=pdf http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.208...
- al_chemist 6y ago
  > I was unable to find the paper the article claims was published about this, which is a shame because I'd love to learn more about what the researchers actually said. https://www.aging-us.com/article/103571 https://www.aging-us.com/article/103571
  - JoshuaDavid 6y ago
    I don't think it's that one, no mention of telomeres anywhere in the article.
    - ksaj 6y ago
      Here's a book (not an article) https://www.ncbi.nlm.nih.gov/books/NBK6486/ https://www.ncbi.nlm.nih.gov/books/NBK6486/ It's been a while since I looked into this. The (simplified) AAAA at the end of a DNA strand gets shorter and shorter upon each reproduction, kinda like an aglet, holding things together until it is too short, and then the strands unwind and get knotted in counterproductive ways, creating unintentional proteins, etc, resulting in disease and eventually death. Our immune system typically notices this happening, and kills off those cells first. Eventually it gets out of control, and population density is maintained. Evolution-wise, this kills off the individual sooner. Population-wise this maintains the population strength since it lowers the energy competition (food, etc) and keeps it balanced.
hikerclimber 6y ago
hopefully whoever got this done to them dies. I hope the world burns.
LinuxBender 6y ago
There have been a few interviews with Bret Weinstein on this topic as it pertains to lab mice. [1] [2] I am curious if this is in any way related and would there be similar concerns around how humans deal with senescent cells and cancer if Telomere are artificially lengthened. Out of curiosity, does anyone in this field have more information to add to Bret's interview that can explain technically how the mice ended up with longer Telomere's and if it was on purpose? [1] - https://www.youtube.com/watch?v=hKTV2R6TT0Y https://www.youtube.com/watch?v=hKTV2R6TT0Y [2] - https://www.youtube.com/watch?v=ve4q-1D_Ajo https://www.youtube.com/watch?v=ve4q-1D_Ajo
pontifier 6y ago
Any time telomeres show up in relation to aging I question it's relevance. I've never seen any causal connection, only correlation. Is there any solid evidence that short telomeres cause aging or that lengthening them actually does anything?

21 points by huntermeyer 6y ago

- "The pressurised chamber allows more oxygen to be dissolved into the tissues and mimics a state of "hypoxia", or oxygen shortage, which is known to have regenerating effects." This seems counter intuitive, anyone know the mechanism here? - Did this article fail to link the paper, or am I failing to see the link? Poor reporting if the former. - There is a gap in reporting here...anyone know exactly how telemeres actually lengthen from this? - Unrelated: Is anyone in the industry actually interested by Brett Weinstein's supposed involvement in lab mice telemere issue discovery, or is he seen as an irrelevant pest within these circles?

tisu32 6y ago
I found the article independently, linked on this reddit thread: https://www.reddit.com/r/longevity/comments/jwnqvu/aging_hyperbaric_oxygen_therapy_increases/ https://www.reddit.com/r/longevity/comments/jwnqvu/aging_hyp...
- chris-orgmenta 6y ago
  Ah thank you. Shame - Red flags throughout that paper, albeit some being self identified.

tisu32 6y ago

From what I can tell as a complete layman, the title is quite sensationalist: the only process being reversed is telomere lengthening, which has a tenuous relationship with aging at best.

pmdulaney 6y ago
Yes, if researchers had really reversed human ageing, do you really think yahoo.com would be breaking the news?
- lern_too_spel 6y ago
  I don't see what relevance that has to this story. Yahoo.com isn't breaking the news, only reporting about an article published in a journal.
  - pmdulaney 6y ago
    Yeah, you're right. I realized it was a dumb comment after I posted it...
ksaj 6y ago
I've actually studied this, and I agree with you. I see a notable difference between "less disease of a very specific sort" and "reversed aging" although the end result is remarkably similar (without the age digression, of course). The article treats them as the same. Unless your sole definition of aging is in re how far down the chain your telomerase shows up. To me, reversing aging would be more like the Benjamin Button story. But that's not the story being told here. Depending on how you are looking at it, they're either very similar things, or completely different things. I see them as being very different.

JoshuaDavid 6y ago

I was unable to find the paper the article claims was published about this, which is a shame because I'd love to learn more about what the researchers actually said. The mechanism described in the Yahoo article is implausible to say the least (TANSTAFFL principle: if you could reverse aging by simply lengthening telomeres, there would have been significant evolutionary pressure for increased expression of telomerase, so unless it came with sufficiently bad downsides, you would expect it to have already reached fixation in the population). Still, I would be interested to see what the researchers themselves actually say. I did find a related article, titled "Telomere elongation followed by telomere length reduction, in leukocytesfrom divers exposed to intense oxidative stress – Implications for tissueand organismal aging" [1]. I would expect the actual findings here were similar to that article. [1] http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.208.4475&rep=rep1&type=pdf http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.208...

al_chemist 6y ago
> I was unable to find the paper the article claims was published about this, which is a shame because I'd love to learn more about what the researchers actually said. https://www.aging-us.com/article/103571 https://www.aging-us.com/article/103571
- JoshuaDavid 6y ago
  I don't think it's that one, no mention of telomeres anywhere in the article.
  - ksaj 6y ago
    Here's a book (not an article) https://www.ncbi.nlm.nih.gov/books/NBK6486/ https://www.ncbi.nlm.nih.gov/books/NBK6486/ It's been a while since I looked into this. The (simplified) AAAA at the end of a DNA strand gets shorter and shorter upon each reproduction, kinda like an aglet, holding things together until it is too short, and then the strands unwind and get knotted in counterproductive ways, creating unintentional proteins, etc, resulting in disease and eventually death. Our immune system typically notices this happening, and kills off those cells first. Eventually it gets out of control, and population density is maintained. Evolution-wise, this kills off the individual sooner. Population-wise this maintains the population strength since it lowers the energy competition (food, etc) and keeps it balanced.

hikerclimber 6y ago

hopefully whoever got this done to them dies. I hope the world burns.

LinuxBender 6y ago

There have been a few interviews with Bret Weinstein on this topic as it pertains to lab mice. [1] [2] I am curious if this is in any way related and would there be similar concerns around how humans deal with senescent cells and cancer if Telomere are artificially lengthened. Out of curiosity, does anyone in this field have more information to add to Bret's interview that can explain technically how the mice ended up with longer Telomere's and if it was on purpose? [1] - https://www.youtube.com/watch?v=hKTV2R6TT0Y https://www.youtube.com/watch?v=hKTV2R6TT0Y [2] - https://www.youtube.com/watch?v=ve4q-1D_Ajo https://www.youtube.com/watch?v=ve4q-1D_Ajo

pontifier 6y ago

Any time telomeres show up in relation to aging I question it's relevance. I've never seen any causal connection, only correlation. Is there any solid evidence that short telomeres cause aging or that lengthening them actually does anything?