It only becomes sensitive to its orientation during the process of changing the angle of the mouse and only then if you rotate the mouse about the dead center.

It only becomes sensitive to its orientation during the process of changing the angle of the mouse and only then if you rotate the mouse about the dead center. For yourself I'd imagine that you only really re-orientate the mouse once per use. Also I'd imagine that you'd quickly start rotating the mouse about the position of the sensor if it was a problem.