3 ms·

What is the average hospitalization and fatality rate among cases where the patient was taking a high dose vitamin D regimen?

junipertea 6y ago
I'm not sure about the combination of covid + vitamin D. But you can also overdose on vitamin D since it's fat soluble. https://www.healthline.com/nutrition/vitamin-d-side-effects#6.-Kidney-failure https://www.healthline.com/nutrition/vitamin-d-side-effects#...
mcguire 6y ago
Anyone remember hydroxychloroquine?
hosh 6y ago
There's a recent quasi-exprimental study on that, showing that vitamin-d is likely one of the central factors in better outcomes for severe cases of covid-19: https://www.sciencedirect.com/science/article/pii/S096007602030296X https://www.sciencedirect.com/science/article/pii/S096007602... According to this study, vitamin-d gives better outcome than the other treatments, including hospitalization: "Regarding care dedicated to COVID-19, only the proportion of patients who received a bolus of vitamin D3 during or just before COVID-19 differed between deceased participants and survivors, with a higher prevalence in survivors (respectively 92.2 % versus 66.7 %, P = 0.023). In contrast, there was no between-group difference in the proportion of patients treated with corticosteroids, hydroxychloroquine or dedicated antibiotics, or hospitalized for COVID-19." And this has to do with Vitamin-D's role with the ACE2 receptor. SARS-CoV-2 has a binding affinity to ACE2, aggressively invading cells with proportionally higher ACE2 receptors (including the lungs). In fact, someone had tried injecting hrsACE2 into someone as a treatment -- that is, letting the virus bind to hrsACE2 instead of the ACE2 receptors in the cells. https://www.nature.com/articles/s41392-020-00374-6 https://www.nature.com/articles/s41392-020-00374-6 A treatment with hrsACE2 isn't generally-available, and needs a lot more study. The logsitics in producing them at scale would need to be solved, if this is a viable treatment. But this looks promising to me.

junipertea 6y ago

I'm not sure about the combination of covid + vitamin D. But you can also overdose on vitamin D since it's fat soluble. https://www.healthline.com/nutrition/vitamin-d-side-effects#6.-Kidney-failure https://www.healthline.com/nutrition/vitamin-d-side-effects#...

mcguire 6y ago

Anyone remember hydroxychloroquine?

hosh 6y ago

There's a recent quasi-exprimental study on that, showing that vitamin-d is likely one of the central factors in better outcomes for severe cases of covid-19: https://www.sciencedirect.com/science/article/pii/S096007602030296X https://www.sciencedirect.com/science/article/pii/S096007602... According to this study, vitamin-d gives better outcome than the other treatments, including hospitalization: "Regarding care dedicated to COVID-19, only the proportion of patients who received a bolus of vitamin D3 during or just before COVID-19 differed between deceased participants and survivors, with a higher prevalence in survivors (respectively 92.2 % versus 66.7 %, P = 0.023). In contrast, there was no between-group difference in the proportion of patients treated with corticosteroids, hydroxychloroquine or dedicated antibiotics, or hospitalized for COVID-19." And this has to do with Vitamin-D's role with the ACE2 receptor. SARS-CoV-2 has a binding affinity to ACE2, aggressively invading cells with proportionally higher ACE2 receptors (including the lungs). In fact, someone had tried injecting hrsACE2 into someone as a treatment -- that is, letting the virus bind to hrsACE2 instead of the ACE2 receptors in the cells. https://www.nature.com/articles/s41392-020-00374-6 https://www.nature.com/articles/s41392-020-00374-6 A treatment with hrsACE2 isn't generally-available, and needs a lot more study. The logsitics in producing them at scale would need to be solved, if this is a viable treatment. But this looks promising to me.