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Sugar does seem to be involved in gout but high fructose corn syrup is basically indistinguishable from sugar metabolically.

• jjav 6y ago
  That is not true. Natural sugar (e.g. sugar cane) is 50% fructose. HFCS is by definition a compound sugar with more than 50% of fructose. How much higher, depends on the manufacturer.
  • JamesBarney 6y ago
    HCFS-42 is high fructose corn syrup with 42% fructose. So you don't need greater than 50% fructose. And the most common high fructose corn syrup is hcfs 55% which is very close to sugar. The scientific consensus is pretty much there won't be any significant changes to your health if you replace sugar with HCFS or vice versa.
• johnyzee 6y ago
  That is wrong. Fructose metabolism specifically differs from other types of sugars, by requiring a particular enzyme, which means it can only be broken down in the liver. https://en.wikipedia.org/wiki/Fructolysis https://en.wikipedia.org/wiki/Fructolysis Unlike glucose, which is directly metabolized widely in the body, fructose is almost entirely metabolized in the liver in humans, where it is directed toward replenishment of liver glycogen and triglyceride synthesis. Under one percent of ingested fructose is directly converted to plasma triglyceride.
  • JamesBarney 6y ago
    No you misread my comment. I never said fructose is indistinguishable from glucose. I said sucrose is almost indistinguishable from high fructose corn syrup. Sucrose is 50% fructose 50% glucose and most high fructose corn syrup is 55% fructose 45% glucose. They are almost identical.
    • johnyzee 6y ago
      Ah, makes sense. When people say 'sugar' they often refer to the different kinds of saccharides, not necessarily sucrose.