Thanks for your detailed reply! I meant that even this dataset puts a limit on the effect size, if viewed as an "evidence of absence of clear and large effect".

Thanks for your detailed reply! I meant that even this dataset puts a limit on the effect size, if viewed as an "evidence of absence of clear and large effect". Of course since "everything is correlated" [0] expecting such truly simple signals might be nonsensical/pointless. I was just lamenting the lack of simple magical treatments basically. [0] https://www.gwern.net/Everything https://www.gwern.net/Everything