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Cell Signaling Technologies – Detailed 3D model of human cells
- sudoankit 6y agoIncredible!
- PikachuEXE 6y agoAgreed But I don't even know enough to know how incredible it is I studied Biology before but had issue remembering the names
- jmiskovic 6y agoVery nice looking and informative. Here's another nice resource for molecular biology art: https://ccsb.scripps.edu/goodsell/ https://ccsb.scripps.edu/goodsell/
- flobosg 6y agoSome additional links: - Drew Berry (https://www.drewberry.com/ https://www.drewberry.com/) - Janet Iwasa (http://onemicron.com/ http://onemicron.com/) - Irving Geis, one of the pioneers in biomolecular art (https://pdb101.rcsb.org/sci-art/geis-archive/about https://pdb101.rcsb.org/sci-art/geis-archive/about)
- jcims 6y agoDrew I recognize from many of the truly remarkable animations from WEHI - https://www.youtube.com/user/WEHImovies/videos https://www.youtube.com/user/WEHImovies/videos
- cee_el123 6y agofor those who are ready for a deep dive - https://www.amazon.com/Fundamentals-Protein-Structure-Function-Engelbert/dp/3319199196 https://www.amazon.com/Fundamentals-Protein-Structure-Functi...
- PetitPrince 6y agoFor those just seeing a huge mess: This is a visualisation of most (everything?) we know about what's in a human cell. It shows molecules (except water some stuff dissolved in it) in their full 3D structure (to scale) . We can actually see the macro structure those can take, e.g. DNA (blue strand at the bottom) is actually a coiled coil, cell membranes (pale golden stuff) is a bilayer, etc. It really shows how busy and complex life is.
- sabujp 6y agoit's not everything at all, it's missing all the cell cycle circadian rhythm stuff
- folli 6y agoIt really is only a small amount of what we know. Look for example at the KEGG pathway list (https://www.genome.jp/kegg/pathway.html https://www.genome.jp/kegg/pathway.html), which is a curated list of pathways (so also only a part of what we know, albeit a larger). And this visualization depicts a dozen or so of these pathways.
- deadOPSEC 6y agoI have no idea what I'm looking at here, but showed it to a molycularbiologist student and she got pretty happy!
- berkeleynerd 6y agoNever thought I’d see my old workplace on the front page of HN. Congratulations everyone! :)
- cee_el123 6y agoAwesome ! As a programmer starting to get acquainted with the stupendous complexity of life at the molecular level - I'm hoping there's many more of us in the months and years to come. It's not possible to overstate the importance of this fact - all these structures and processes evolved - weren't designed - but evolved ! It's also incredible how scientists keep breaking through all kinds of scale related barriers to successfully study them
- jjoe 6y agoIt's not possible to overstate the importance of this fact - all these structures and processes evolved - weren't designed - but evolved ! Why not: designed to evolve
- fdej 6y agoAnd then why not: the designer originated through evolution. Which in turn...
- carapace 6y agoIt's an interesting idea: if we eventually learn to control time, perhaps we are/become the telos of the Universe? > His posthumously published book, The Phenomenon of Man, set forth a sweeping account of the unfolding of the cosmos and the evolution of matter to humanity, to ultimately a reunion with Christ. In the book, Teilhard abandoned literal interpretations of creation in the Book of Genesis in favor of allegorical and theological interpretations. The unfolding of the material cosmos is described from primordial particles to the development of life, human beings and the noosphere, and finally to his vision of the Omega Point in the future, which is "pulling" all creation towards it. He was a leading proponent of orthogenesis, the idea that evolution occurs in a directional, goal-driven way. Teilhard argued in Darwinian terms with respect to biology, and supported the synthetic model of evolution, but argued in Lamarckian terms for the development of culture, primarily through the vehicle of education.[15] Teilhard made a total commitment to the evolutionary process in the 1920s as the core of his spirituality, at a time when other religious thinkers felt evolutionary thinking challenged the structure of conventional Christian faith. He committed himself to what the evidence showed.[16] > Teilhard made sense of the universe by assuming it had a vitalist evolutionary process.[17][18] He interprets complexity as the axis of evolution of matter into a geosphere, a biosphere, into consciousness (in man), and then to supreme consciousness (the Omega Point). https://en.wikipedia.org/wiki/Pierre_Teilhard_de_Chardin https://en.wikipedia.org/wiki/Pierre_Teilhard_de_Chardin
- userman 6y agoFly hackin
- prower 6y agoA little context? Are these CGI?
- pas 6y agoBasically yes. But the proteins, sizes, shapes are based on real sizes/microscopy, with added depth, and with a lot of clutter removed.
- fabian2k 6y agoIt's a very interesting visualization, but probably not understandable without quite a bit of cell biology knowledge. The scale seems wrong in some cases, though I'm not entirely sure. The mitochondria look far too small to me. For the ER which is similarly small it is quite clear that it's only showing a tiny subsection. In other parts the scale looks pretty good. And it does manage to convey how busy cells are a bit better than many visualizations. For the audience here it might be worth emphasizing that these are pretty close zooms on cells, you can see individual proteins here. If you imagine an image of a cell, each visualization shown here is maybe a single pixel of that full image of a cell (I'm probably off by an order of magnitude here or two).
- ampdepolymerase 6y agoThat is correct, the magnitudes seem to be squashed so they all are within the same magnitude. In reality the size differences are huge.
- TeeWEE 6y agoThis is amazing. Life is technology to its finest. Nanomachines working together and keeping the whole cell machine running, all the cells working together to produce a machine that can walk an talk: Animals. Humans. Amazing.... Whenever I feel sad, reading about DNA, Ribosomal machines, and the complexity of a single cell makes me feel special. Life is the most complex organization of molecules and live emerges from the universe.. Its amazing to see we're all such a complex machine.
- kharak 6y agoMy next side project is completing the 101 bioengineering course from The Odin. I really want to have a basic understanding of what's going on in biology. Someone here did something similar or can recommend some resources?
- cee_el123 6y agohttps://www.amazon.com/Fundamentals-Protein-Structure-Function-Engelbert/dp/3319199196 https://www.amazon.com/Fundamentals-Protein-Structure-Functi... there's another book called cell biology by Alberts et al
- gewa 6y agoBiochemistry by Jeremy M. Berg, John L. Tymoczko and Lubert Stryer is a widespread introduction to Biochemistry.
- hanklazard 6y agoI worked in a Cell Biology lab for my graduate work and we did quite a bit of business with this company. They would send us really cool, informative posters, but these examples are really next level. I would love a large, high quality print of one of these, I’d frame it and put it up in my house.
- basilisks 6y agoThe title is misleading—Cell Signaling Technologies is a company. This appears to be Digizyme’s portfolio of work they have done for their client, Cell Signaling Technologies.