Which processes really require occupying and allocating bigger blocks of RAM? It's not uncommon to work with e.g. 50GB+ databases these days. They don't

Which processes really require occupying and allocating bigger blocks of RAM? It's not uncommon to work with e.g. 50GB+ databases these days. They don't always need to be in RAM, particularly with modern SSD performance, but if you're using a laptop for your day job and you work with largeish data...