We should be clear about the goalposts. Reducing the transmission rate to a manageable level will be very easy with even just some fraction of the population be

We should be clear about the goalposts. Reducing the transmission rate to a manageable level will be very easy with even just some fraction of the population being vaccinated. What exact percentage is unclear, but it's a lot less than 100%. No realistic number of anti-vaxxers can change that. Eradicating the virus is a whole different goal, and there could be lots of different impediments to that. After all, we still get vaccinated for a large numbers of illnesses that we haven't eradicated but are just very rare. That's not a terrible endgame for COVID.