2 ms·

Sounds like it’s an impossible problem. I remember people saying AIDS was impossible to treat. It took less than 10 years to find a treatment. I’m in the cam

Sounds like it’s an impossible problem. I remember people saying AIDS was impossible to treat. It took less than 10 years to find a treatment. I’m in the camp that believes we will eventually find a solution sooner or later. I was hoping for sooner.

selectodude 6y ago
I'd like to hope that nothing is impossible but a cure for abdominal cancers is going to be one of the last cancers we figure out. They're basically perfect as far as being difficult to kill.
toomuchtodo 6y ago
It takes about a year for pancreatic cancer to go from stage one to stage four. With improved biomarker detection in biannual blood tests, I think we’d make a lot of headway to earlier detection, with CRISPR for (more effective) immunotherapy treatment (vs surgery and chemo). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813368/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813368/
- selectodude 6y ago
  Easier said than done, unfortunately. https://www.targetedonc.com/view/challenges-persist-with-car-tcell-therapy-in-pancreatic-cancer https://www.targetedonc.com/view/challenges-persist-with-car...
  - melling 6y ago
    I don’t think anyone is saying it’s going to be easy. I simply wish we would have more of a “can do” attitude rather than “it’s a really hard problem. There’s nothing more we can do“
    - iancmceachern 6y ago
      I also will miss him. He and Jeopardy were a fixture in our home, and life. What a great human. I'm willing to work on this. I have lots of relevant experience, and a can do attitude. I've tackled (mostly successfully) similar challenges like artificial hearts, dialysis, AI and surgical robots. Coincidentally I'm giving a talk on making an artificial heart in 45 mins at the hackaday remoticon: https://www.eventbrite.com/e/remoticon-tickets-115886905855 https://www.eventbrite.com/e/remoticon-tickets-115886905855 I'm confident we could solve this problem. Lets do it.
      - panabee 6y ago
        1. how do we match talented people like you with organizations who could use help? 2. how can we model medicine to be more like open-source, where talented individuals can contribute in surgical ways, in case they can't afford to quit their jobs and focus on healthcare 100%?
- mlyle 6y ago
  Maybe. But earlier detection isn't the panacea that we thought it might be in cancer. The problem is--- staging isn't independent of the cancer's aggressiveness. If you detect a cancer at stage 2, it may be "earlier" detection, or it may be a much less aggressive cancer than one that would have reached stage 4 by the same point.
mensetmanusman 6y ago
~ 1 million people a year die of HIV/AIDS... It is endemic, which is why we don’t have a global lockdown for it, but it is still there killing about the same number of people as automobiles.

selectodude 6y ago

I'd like to hope that nothing is impossible but a cure for abdominal cancers is going to be one of the last cancers we figure out. They're basically perfect as far as being difficult to kill.

toomuchtodo 6y ago

It takes about a year for pancreatic cancer to go from stage one to stage four. With improved biomarker detection in biannual blood tests, I think we’d make a lot of headway to earlier detection, with CRISPR for (more effective) immunotherapy treatment (vs surgery and chemo). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813368/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813368/

selectodude 6y ago
Easier said than done, unfortunately. https://www.targetedonc.com/view/challenges-persist-with-car-tcell-therapy-in-pancreatic-cancer https://www.targetedonc.com/view/challenges-persist-with-car...
- melling 6y ago
  I don’t think anyone is saying it’s going to be easy. I simply wish we would have more of a “can do” attitude rather than “it’s a really hard problem. There’s nothing more we can do“
  - iancmceachern 6y ago
    I also will miss him. He and Jeopardy were a fixture in our home, and life. What a great human. I'm willing to work on this. I have lots of relevant experience, and a can do attitude. I've tackled (mostly successfully) similar challenges like artificial hearts, dialysis, AI and surgical robots. Coincidentally I'm giving a talk on making an artificial heart in 45 mins at the hackaday remoticon: https://www.eventbrite.com/e/remoticon-tickets-115886905855 https://www.eventbrite.com/e/remoticon-tickets-115886905855 I'm confident we could solve this problem. Lets do it.
    - panabee 6y ago
      1. how do we match talented people like you with organizations who could use help? 2. how can we model medicine to be more like open-source, where talented individuals can contribute in surgical ways, in case they can't afford to quit their jobs and focus on healthcare 100%?
mlyle 6y ago
Maybe. But earlier detection isn't the panacea that we thought it might be in cancer. The problem is--- staging isn't independent of the cancer's aggressiveness. If you detect a cancer at stage 2, it may be "earlier" detection, or it may be a much less aggressive cancer than one that would have reached stage 4 by the same point.

mensetmanusman 6y ago

~ 1 million people a year die of HIV/AIDS... It is endemic, which is why we don’t have a global lockdown for it, but it is still there killing about the same number of people as automobiles.