One way to answer this is to point out that an anecdote always comes with its own replication crisis. The term "replication crisis" is essentially a generaliza

One way to answer this is to point out that an anecdote always comes with its own replication crisis. The term "replication crisis" is essentially a generalization of the concept of an anecdote. In other words, if a result can't be reproduced, then it's essentially just an anecdote. So, your (rightful) mention of the replication crisis gives you a direct explanation for why anecdotal evidence is inherently problematic in the scientific endeavour for knowledge.