> I've also read of some interesting work being done creating "anti-abuse" formulations, where the active ingredients are compounded with Niacin or other drugs

> I've also read of some interesting work being done creating "anti-abuse" formulations, where the active ingredients are compounded with Niacin or other drugs that cause unpleasant physical side effects at high doses to discourage overdose/abuse/recreational use. Of course they can’t just let us use the natural substance that has existed for most, of not all, of human history.