Is there any research on the adverse affects of quickly relieving depression medicinally, or the role of non-clinical depression in the psychology and function

Is there any research on the adverse affects of quickly relieving depression medicinally, or the role of non-clinical depression in the psychology and function of a person? I ask because I realize the need and desire to relieve many people who suffer from clinical depression that totally derails their life or ability to function, but I always wonder at the possible function of some depression in the normal functioning of the psychology of a person. Does the effect of psilocybin wear off if used too often?