Treatment resistant depressive here. After three decades of trying different therapeutic treatment avenues, including many pharma and non-pharma options, I thi

Treatment resistant depressive here. After three decades of trying different therapeutic treatment avenues, including many pharma and non-pharma options, I think that refractory (treatment resistant) depression is a phenomenon rooted in biochemistry. At least for me, disconnect from other people/society doesn’t play a role (plenty of connections, happily married, etc.). In my case, pharma pretty much works, non-pharma hasn’t. This doesn’t exclude non-pharma therapies’ being effective - for example, they may modulate underlying biochem to good effect in some- but only that such treatments haven’t worked for me. I’m following the pscilocybin work closely. So far, it’s encouraging. I plan to experiment in 2021.