Apparently, SSRIs work really well for some people. I know a person who is night and day difference on them. She was crying a lot and sluggish without them,

Apparently, SSRIs work really well for some people. I know a person who is night and day difference on them. She was crying a lot and sluggish without them, down right jolly with them. As far as the default mode network, I've seen research that claims hyperactivity of the DMN causes rumination, which puts you in a downward spiral. So perhaps a bit of inhibition is good.