4 ms·

I think the primary reason for “normal” psych meds is they’ve been tested well for harm reduction first and foremost. That’s why the front line SSRIs are front

I think the primary reason for “normal” psych meds is they’ve been tested well for harm reduction first and foremost. That’s why the front line SSRIs are front line, they have less chance of a negative effect. Downside is it’s mild, and there’s plenty of evidence that the “low seratonin” theory of depression doesn’t apply to many. Psilocybin is an intense acute experience. People can have negative effects. I hope we do studies to find how to use it most safely, or isolate the beneficial aspect without the intoxicating effects.

cwkoss 6y ago
The research and anecdotal reports coming out about microdosing is pretty exciting for the field of depression treatment. Though some take greater dosages, many people are finding relief from sub-perceptual doses: indicating that the typical hallucinations and disorientation associated with recreational psilocybe use is likely not necessary for achieving anti-depressive effect. I've also read of some interesting work being done creating "anti-abuse" formulations, where the active ingredients are compounded with Niacin or other drugs that cause unpleasant physical side effects at high doses to discourage overdose/abuse/recreational use. "Stamet's stack" seems to be the most common of these. Definitely needs much more research into these compounds, but seems a very promising frontier for antidepressant pharmacology.
- LocalH 6y ago
  > I've also read of some interesting work being done creating "anti-abuse" formulations, where the active ingredients are compounded with Niacin or other drugs that cause unpleasant physical side effects at high doses to discourage overdose/abuse/recreational use. Of course they can’t just let us use the natural substance that has existed for most, of not all, of human history.

4 ms·

I think the primary reason for “normal” psych meds is they’ve been tested well for harm reduction first and foremost. That’s why the front line SSRIs are front

by taurath 6y ago

cwkoss 6y ago
The research and anecdotal reports coming out about microdosing is pretty exciting for the field of depression treatment. Though some take greater dosages, many people are finding relief from sub-perceptual doses: indicating that the typical hallucinations and disorientation associated with recreational psilocybe use is likely not necessary for achieving anti-depressive effect. I've also read of some interesting work being done creating "anti-abuse" formulations, where the active ingredients are compounded with Niacin or other drugs that cause unpleasant physical side effects at high doses to discourage overdose/abuse/recreational use. "Stamet's stack" seems to be the most common of these. Definitely needs much more research into these compounds, but seems a very promising frontier for antidepressant pharmacology.
- LocalH 6y ago
  > I've also read of some interesting work being done creating "anti-abuse" formulations, where the active ingredients are compounded with Niacin or other drugs that cause unpleasant physical side effects at high doses to discourage overdose/abuse/recreational use. Of course they can’t just let us use the natural substance that has existed for most, of not all, of human history.