3 ms·
What’s the pathophysiology of frozen shoulder?
by bionhoward 6y ago
What’s the pathophysiology of frozen shoulder?
- bionhoward 6y agoBiological Aspect of Pathophysiology for Frozen Shoulder https://www.hindawi.com/journals/bmri/2018/7274517/ https://www.hindawi.com/journals/bmri/2018/7274517/ Would be potentially useful to get yourself genetic sequence and/or biopsy and RNASEQ because you could identify which genes are up or down regulated to cause the condition, and theoretically you could treat this with something like RNA interference. For example if your frozen shoulder is caused by reduced production of the Matrix Metalloproteins which break down collagen, then you could either reduce collagen production or insert additional copies of the MMP genes. Or, if the frozen shoulder mechanism is directly immunologic, it could be autoimmune, in which case you could try to induce tolerance with some supressive immunotherapy as has been effective for some folks with Asthma. Another possibility would be the frozen shoulder is an overt manifestation of another underlying condition, such as rheumatoid arthritis, lupus, or cancer (paraneoplastic frozen shoulder) If the pain is truly unbearable, you could look at more distal nerve blocks, or sensory-only nerve blocks, perhaps you could try a clinical trial for NaV1.7 knockdown (to turn off a critical pain gene in a local area, such as the dorsal root ganglion for the correct dermatome) Not a doc but did pass USMLE before switch to engineering. Hope it helps. Feel better dude!