I think you use what works best for your problem set taking into account your expertise. I'm using (no demo available yet) nodejs, express, socket.io, and yQue

I think you use what works best for your problem set taking into account your expertise. I'm using (no demo available yet) nodejs, express, socket.io, and yQuery together. There's a jQuery wrapper out there for use with node, I think. jQuery makes my life easier on the display side, but I can see how if I had real-deal-holyfield javascript chops I'd gravitate to DIY or some slimmer framework.