Definitely depends on your audience. If you have a tech-savvy audience, it's a good bet that the vast majority of your site's visitors are at 1024px. But if y

Definitely depends on your audience. If you have a tech-savvy audience, it's a good bet that the vast majority of your site's visitors are at 1024px. But if you're targeting, say, a certain subset of baby boomers who may not have upgraded their computers in a while, accommodating 800px might be a good idea. One thing you can do is find a very popular Web site (like at the Amazon / Ebay / Facebook level) that targets the same audience you do and see what they're doing with their design.