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I don't know. You're talking about the engagement of the pancreas itself and I am talking about the effects of that engagement on the entire body. I note with

• manicorganic 6y ago
  Ideally you want no spikes, because you are eating a balanced diet and avoiding meals and snacks consisting largely of refined carbs and refined sugars. A proper meal shouldn't really create a blood sugar (and resulting insulin) spike as much as a gradual elevation and fall back to baseline, because protein, fat, and fiber all slow digestion, and complex carbs (and even sugars within fiber/nutrient matrixes ie whole fruits) don't tend to spike blood sugar too badly in the first place.