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My suspicion is that you would see similar improvement with things like waist circumference, BMI, blood pressure, at least initially, but that the difference wi
by ravenstine 6y ago
My suspicion is that you would see similar improvement with things like waist circumference, BMI, blood pressure, at least initially, but that the difference with intermittent fasting is that it introduces enough of a "fasted state" that the body is able to perform repair and autophagy of senescent cells that would occur much less in a constantly fed state. (something about telomerase, but I probably shouldn't mention that because my memory about that is foggy)
If you increased the amount of fasting, I'd bet good money that people would lose more weight than on a calorie-equivalent diet. Intermittent fasting, in my experience, is helpful in sticking to a diet that is lower in calories because it allows you to eat satisfying meals.
- voisin 6y agoFrom what I understand, autophagy doesn’t start until 18 hours and doesn’t peak until 72 hours.
- JohnGB 6y agoAutophagy is always active, the real question is how that activity changes during fasting. The number of 18 hours is fairly arbitrary, as even after a few hours of fasting autophagy increases.
- rmoriz 6y agoAutophagy is not a binary thing. Every body does autophagy all the time, it's the intensity/volume that increases in longer fasts.
- ravenstine 6y agoI've never heard of that 18 hour rule. It's funny because I've read a lot about fasting, but this is news to me, and it seems like this is reported from multiple sources. But I can't seem to find any authoritative references.
- shock 6y agoThe Japanese researcher that got a Nobel Prize for discovering the autophagy mechanisms has a course on edx. Doesn't get much more authoritative than that.
- mrfusion 6y agoI’ve been looking for a good source but haven’t found one. Has it not been studied in humans yet?
- voisin 6y agoI think I heard it on the FoundMyFitness podcast which has excellent discussions about fasting science. I think it may have been the last interview with Valter Longo. I’ll see if I can dig it up, but their website would be a good starting point.
- markdown 6y ago"Someone said so in an interview" isn't really compelling evidence. Do you know of actual evidence of this? Studies?
- deleted 6y ago[deleted]
- hombre_fatal 6y agoFeel free to pore over thousands of scientific papers about the benefits of fasting on NCBI for us and let us know. Until then, I'll take NutritionFacts.org videos' word for it: https://www.youtube.com/channel/UCddn8dUxYdgJz3Qr5mjADtA https://www.youtube.com/channel/UCddn8dUxYdgJz3Qr5mjADtA which cites scientific papers as it makes claims.
- _-___________-_ 6y agoNo idea why you're being downvoted. Even when videos/podcasts cite studies, it's difficult to verify that the study actually supports their claim since it's often difficult to find the study they mention. The 18 hour claim may be supported by evidence, but there isn't any in this subthread so far.
- ConcernedCoder 6y agohttps://www.tandfonline.com/action/journalInformation?show=aimsScope&journalCode=kaup20 https://www.tandfonline.com/action/journalInformation?show=a...
- tracker1 6y agoDepends on what you're eating... if you're on a keto (fast mimicking) macro level intake, you'll reach autophagy a bit faster. Heavy exercise/resistance/lifting can also help speed this up, which can also lend to timing of exercise and food intake.