> The only ones I can really think of are drugs with long-term unexpected side effects or a response to an equally massive cause like the Carrington Event coron

> The only ones I can really think of are drugs with long-term unexpected side effects or a response to an equally massive cause like the Carrington Event coronal mass ejection which blew out the electrical grid in 1859. I'd count the mass ejection as a natural disaster rather than the failure of a system, but the harm is just the same of course. Related to your medicine example: bad dietary advice could be similar to this. We're straying some ways from technological systems here, of course.