In bioinformatics, MCMC was used often linkage analysis to sample a "genotype space" of a true inheritance pattern of multiple related individuals to find the l

In bioinformatics, MCMC was used often linkage analysis to sample a "genotype space" of a true inheritance pattern of multiple related individuals to find the location and transmission pathway of disease causing variants. Classical genetics and statistics were very tightly linked in this regard due to scarcity of data at the time (pre-2000). Now that the field has exploded with big data, such statistics are no longer so neccesary to answer the same problems, and a lot of the early mathematical elegance associated with the field has given way to brute-force filtering methods.